grant
Expanded evaluation of the role of antibody-dependent innate effector function in TB disease progression in HIV co-infected individuals
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 12 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAb responseAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAnti-HIV PositivityAntibodiesAntibody FormationAntibody ProductionAntibody RepertoireAntibody ResponseAssayAutomobile DrivingBioassayBioinformaticsBiological AssayBiological MarkersBiologyBlood NeutrophilBlood PlasmaBlood Polymorphonuclear NeutrophilBlood SerumBlood monocyteCause of DeathCell BodyCell Culture TechniquesCellsCharacteristicsClinicalCommunicable DiseasesComplementComplement ProteinsComputer ModelsComputerized ModelsDataDepositDepositionDevelopmentDiseaseDisease ProgressionDisorderEffector CellEngineeringEnsureEvaluationFc ReceptorFc domainFortuneGeneralized GrowthGrowthHIVHIV AntibodiesHIV PositiveHIV PositivityHIV SeroconversionHIV SeronegativitiesHIV SeronegativityHIV SeropositivityHIV antibody positiveHIV negativeHIV-1HIV-Associated AntibodiesHIV-IHIV/MtbHIV/TBHIV/mycobacterium tuberculosisHIV/tuberculosisHIV1HTLV-III AntibodiesHTLV-III SeroconversionHTLV-III SeronegativitiesHTLV-III SeronegativityHTLV-III SeropositivityHTLV-III-LAV AntibodiesHospitalsHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III AntibodiesHuman immunodeficiency virus 1ImmuneImmune responseImmunesImmunochemical ImmunologicImmunoglobulin DomainImmunoglobulin-Like DomainImmunologicImmunologicalImmunologicallyImmunologicsImmunologyImmunomodulationIn VitroIndividualInfectionInfection ControlInfectious DiseasesInfectious DisorderInflammatoryInnate ImmunityInternationalLAV AntibodiesLAV-HTLV-IIILinkLong-term cohortLongitudinal cohortLymphadenopathy-Associated AntibodiesLymphadenopathy-Associated VirusM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM. tuberculosis/HIVM.tb infectionM.tuberculosis infectionMTB infectionMarrow NeutrophilMarrow monocyteMeasuresMediatingMedicineMentorsMethodologyModelingModern ManModificationMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNK Cell ActivationNative ImmunityNatural ImmunityNatural Killer Cell ActivationNeutrophilic GranulocyteNeutrophilic LeukocyteNon-Specific ImmunityNonspecific ImmunityOutcomePathogenesisPathogenicityPathologicPatientsPersonsPhagocytosisPlasmaPlasma SerumPlayPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsProgram DevelopmentPublic Health SchoolsPublishingResearchReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleSamplingSerologySerumSiteSystemTB infectionTestingTherapeuticTimeTissue GrowthTrainingTranslational Research EnterpriseTuberculosisVaccinesVirus-HIVWhole BloodWomananti-microbialantibody biosynthesisantibody receptorantimicrobialbio-markersbiologic markerbiomarkercareer developmentcell culturecell culturescell typeco-infectioncohortcoinfectioncomplementationcomputational modelingcomputational modelscomputer based modelscomputerized modelingdevelopmentaldisease controldisease riskdisorder controldisorder riskdisseminated TBdisseminated tuberculosisdrivinghigh dimensionalityhost responseimmune modulationimmune regulationimmune system responseimmunoglobulin biosynthesisimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinfection due to Mycobacterium tuberculosisinnovateinnovationinnovativeinsightinstructorinterdisciplinary approachmonocytemtbmultidisciplinary approachmycobacterialneutrophilnew diagnosticsnext generation diagnosticsnovelnovel diagnosticsontogenypatient profilepost-doctoral trainingpredictive signatureprofiles in patientsprogression riskreceptor bindingreceptor boundrecruitresponsesocial roletranslation research enterprisetranslational research programtuberculosis infectiontuberculous spondyloarthropathy
Description preview
PROJECT SUMMARY/ABSTRACT
HIV is the most important risk factor for progression to active tuberculosis (TB), but the immunologic
mechanisms for this increased rate of progression are incompletely defined. Antibodies serve an important role
coordinating the innate and adaptive immune compartments through the Fc-domain of the immunoglobulin…
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