grant
Exogenous fatty acid utilization by Staphylococcus aureus
Organization UNIVERSITY OF KANSAS MEDICAL CENTERLocation KANSAS CITY, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20259-Octadecenoic Acid9-hexadecenoic acidAcetyl CoAAcetyl Coenzyme AActivities of Daily LivingActivities of everyday lifeAmino Acid SubstitutionAnabolismAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibioticsAntisepticsAssayAutoregulationBacteriaBacterial PhysiologyBand Shift Mobility AssayBandshift Mobility AssayBindingBioassayBiochemicalBiological AssayBiological TestingCarbonCarrier ProteinsCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell RespirationCell SignalingCellsCellular ExpansionCellular FunctionCellular GrowthCellular PhysiologyCellular ProcessCellular RespirationComplementComplement ProteinsComplexCoupledCryo-electron MicroscopyCryoelectron MicroscopyDataDegradation PathwayDegradative PathwayDevelopmentDisease OutcomeE coliE. coliElectron CryomicroscopyElectrophoretic Mobility Shift AssayEnergy-Generating ResourcesEnvironmentEscherichia coliEssential Fatty AcidsFatty AcidsFree Fatty AcidsGene ExpressionGene TranscriptionGenerationsGenesGenetic TranscriptionGenetics-MutagenesisGram-Positive BacteriaHarvestHomeostasisHuman FigureHuman bodyInfectionInfectious Skin DiseasesIntegral Membrane ProteinIntermediary MetabolismIntracellular Communication and SignalingIntrinsic Membrane ProteinKinasesLDLLDL LipoproteinsLifeLipidsLocal Anti-Infective AgentsLow-Density LipoproteinsMammaliaMammalsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMembraneMetabolicMetabolic ProcessesMetabolismMiscellaneous AntibioticMobility Shift AssayMolecular InteractionMutagenesisMutagenesis Molecular BiologyNonesterified Fatty AcidsOleic AcidsPathogenicity FactorsPathway interactionsPersonsPhosphotransferase GenePhosphotransferasesPhotometryPhysiological HomeostasisPlantsPlasmidsPositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProductionPropertyProtein ModificationProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqRegulationReporterReportingRepressionResearchResistanceRespirationRoentgen RaysRoleS aureusS-acetate Coenzyme AS. aureusSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSkinSourceStaph aureusStaphylococcus aureusStructureSubcellular ProcessSystemTM DomainTestingTopical Anti-Infective AgentsTranscriptionTransmembrane DomainTransmembrane ProteinTransmembrane Protein GeneTransmembrane RegionTransphosphorylasesTransport Protein GeneTransport ProteinsTransporter ProteinUnsaturated Fatty AcidsVirulence FactorsX-RadiationX-Ray RadiationX-rayXrayaerobic metabolismaerobic respirationanti-bacterialbeta-Lipoproteinsbiological signal transductionbiosynthesiscell growthcis-9-Octadecenoic Acidcombatcomplementationcryo-EMcryoEMcryogenic electron microscopycutaneous infectiondaily living functiondaily living functionalitydevelopmentalenergy sourcefunctional abilityfunctional capacitygel shift assayglobal healthhuman diseasehuman pathogeninfected skininhibitormembrane structuremembrane synthesismutantnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoxidative metabolismpalmitoleic acidpathogenpathwayresistantrespiratory mechanismresponseskin infectionsocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic agent developmenttherapeutic developmenttooltranscriptome sequencingtranscriptomic sequencing
Description preview
PROJECT SUMMARY
Fatty acids are an indispensable part of life since they are an essential component of membranes. In addition,
they can serve a variety of other purposes, from an energy source to part of signaling molecules. Most bacteria
can generate their own fatty acids through a biosynthesis pathway. However, bacteria can also scavenge fatty…
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