grant
Exercise Mimetics for Dementia and Alzheimer's Disease
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Feb 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202621+ years old65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD dementiaAD modelAD pathologyAD therapyAD treatmentAPP processingAddressAdultAdult HumanAffectAged 65 and OverAgingAgonistAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease treatmentAlzheimer sclerosisAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease therapyAlzheimer's pathologyAlzheimer's therapyAlzheimers DementiaAmentiaAmericanAmmon HornAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnimal ModelAnimal Models and Related StudiesApplications GrantsAstrocytesAstrocytusAstrogliaAβBiochemicalBody TissuesBrainBrain Nervous SystemCell BodyCell LineCell RespirationCellLineCellsCellular RespirationChemicalsClinicalClinical EvaluationClinical TestingCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCornu AmmonisCytoskeletal GeneCytoskeletal ProteinsDataDegenerative Neurologic DisordersDementiaDepositDepositionDevelopmentDiseaseDisorderDisturbance in cognitionDrug TherapyER-BETAERalphaERbetaERαERβESR-BETAESR1ESR1 geneESR2ESR2 geneESRBESTRBEncephalonEstradiol Receptor alphaEstradiol Receptor αEstrogen Receptor 1Estrogen Receptor 2Estrogen Receptor alphaEstrogen Receptor betaEstrogen Receptor αEstrogen Receptor βEstrogen ReceptorsEstrogensExerciseGene TranscriptionGenetic TranscriptionGoalsGrant ProposalsHippocampusHortega cellImpaired cognitionImpairmentIndependent LivingIndividualIntermediary MetabolismKO miceKnock-out MiceKnockout MiceLanguageLearningLigand BindingLigandsMacrophageMedicinal ChemistryMemoryMemory LossMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMicrogliaModelingMotorMurineMusMφNR3A1NR3A2NamesNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeuritic PlaquesNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurologic Degenerative ConditionsNeuronsNuclear Orphan ReceptorNuclear ReceptorsNull MouseOrphanOxidative RegulationPeripheralPharmaceutic ChemistryPharmaceutical ChemistryPharmacological TreatmentPharmacotherapyPlayPrimary Senile Degenerative DementiaPropertyRNA ExpressionReceptor ProteinResearchRoleSchemeSenile PlaquesSkeletal MuscleStrains Cell LinesSynthetic EstrogensTherapeutic EstrogenTissuesTranscriptionVoluntary Musclea beta peptideabetaabeta depositionabove age 65adulthoodaerobic metabolismaerobic respirationafter age 65age 65 and greaterage 65 and olderage 65 or olderageage of 65 years onwardaged 65 and greateraged 65+aged miceaged mouseaged ≥65aging processalzheimer modelamyloid betaamyloid beta depositionamyloid beta plaqueamyloid precursor protein processingamyloid β depositionamyloid-b plaqueamyloid-b proteinastrocytic gliaaβ depositionaβ plaquesbeta amyloid fibrilclinical candidateclinical testcognitive dysfunctioncognitive enhancementcognitive functioncognitive losscored plaquecultured cell linedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdevelopmentaldiffuse plaquedrug discoverydrug interventiondrug treatmentelderly miceestrogen receptor proteinestrogen-related receptorestrophileestrophilinexecutive controlexecutive functionextracellulargitter cellgray matterhippocampalhuman old age (65+)hyper-phosphorylated tauhyperphosphorylated tauimprovedmemory declinemesogliamicroglial cellmicrogliocytemimeticsmodel of animalmouse modelmurine modelnamenamednamingneurocognitive disorderneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurogenesisneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyold miceover 65 yearsoxidative metabolismperivascular glial cellpharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsprimary degenerative dementiareceptorresearch clinical testingsenile dementia of the Alzheimer typesocial cognitionsocial rolesoluble amyloid precursor proteinsubstantia griseasynthetic estrogenic compoundtangletoolxenoestrogen≥65 years
Description preview
Project Summary
Dementia or major neurocognitive disorder is a condition of significant cognitive decline that impairs
independent living. Learning and memory, executive function, perceptual-motor function, social cognition, and
language may be affected. Although dementia is typically associated with aging, it is not a natural component
of the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click