grant
Exercise adherence and cognitive decline: Engaging with the Black community to develop and test a goal-setting and exercise intensity intervention
Organization UNIVERSITY OF COLORADOLocation Boulder, UNITED STATESPosted 18 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202521+ years old65 and older65 or older65 years of age and older65 years of age or more65 years of age or older65+ years65+ years oldAD dementiaAD related dementiaADRDAPOEAdherenceAdoptedAdultAdult HumanAffectAffectiveAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfro AmericanAfroamericanAgeAge associated cognitive deficitAge associated cognitive dysfunctionAge related memory declineAge related memory deficitAge related memory impairmentAge-associated cognitive declineAge-related cognitive declineAged 65 and OverAgingAllelesAllelomorphsAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmericanAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinApo-EApoE proteinApolipoprotein EAreaArteriosclerotic DementiaAwarenessAβBehaviorBenchmarkingBenign senescent forgetfulnessBest Practice AnalysisBiologicalBiological MarkersBlackBlack AmericanBlack raceBlood PlasmaCardiovascular DiseasesChronic DiseaseChronic IllnessCodeCoding SystemCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollaborationsCommunitiesDataDemographic FactorsDevelopmentDiabetes MellitusDisparitiesDisparityDisturbance in cognitionEffectivenessEffectiveness of InterventionsEquityEthnic OriginEthnicityExerciseExercise routineFeedbackGenesGeneticGenotypeGoalsGuidelinesHealthHealth behavior and outcomesImmigrantImmigrant communityImpaired cognitionIndividualInterventionIntervention TrialInterventional trialLife StyleLifestyleLightLiteratureMT-bound tauMaintenanceMeasuresMediatingMediatorMeta-AnalysisMethodsModerate ExerciseMorbidityMorbidity - disease rateNon-HispanicNonhispanicNot Hispanic or LatinoOutcomeParticipantPersonsPhasePhotoradiationPhysical activityPlasmaPlasma SerumPopulationPrevalencePreventionPrimary Senile Degenerative DementiaProcessPublic HealthRaceRacesRandomization trialRecommendationReportingResearchResearch DesignReticuloendothelial System, Serum, PlasmaRiskSamplingSelf EfficacyStrenuous ExerciseStructural RacismStudy TypeSystemTechniquesTestingTranslatingTreatment EfficacyUnderrepresented GroupsUnderrepresented PopulationsVascular DementiaVulnerable PopulationsWorkWorld Health Organizationa beta peptideabetaabove age 65acceptability and feasibilityadulthoodafter age 65age 65 and greaterage 65 and olderage 65 or olderageage associatedage associated cognitive impairmentage associated memory declineage associated memory deficitage correlatedage dependentage linkedage of 65 years onwardage relatedage related cognitive deficitage related cognitive dysfunctionage related cognitive impairmentage related memory dysfunctionage specificage-associated memory impairmentage-induced cognitive declineage-related decline in cognitionage-related decline in cognitive functionaged 65 and greateraged 65+aged ≥65agesaging related cognitive declineamyloid betaamyloid-b proteinbehavior adherencebehavioral adherencebenchmarkbeta amyloid fibrilbio-markersbiologicbiologic markerbiomarkercardiovascular disordercerebrovascular contributions to dementiachronic disordercognitive dysfunctioncognitive losscommunity advisory boardcommunity advisory committeecommunity advisory panelcommunity engaged participatory researchcommunity engaged researchcommunity engagementcommunity partnered researchcommunity partnerscommunity-based partnerscommunity-engaged studycommunity-partnered studycompliance behaviordesigndesigningdevelopmentaldiabetesdisparity in healtheconomic costefficacy testingengagement with communitiesexercise adherenceexercise intensityexercise interventionexercise regimenfeasibility trialgroup of colorhealth disparityhuman old age (65+)hyper-phosphorylated tauhyperphosphorylated tauindividual of colorintense exerciseintervention effectintervention efficacyintrinsic motivationmeetingmeetingsmembermetropolitanmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmoderate physical activitymoderate-to-vigorous physical activitymortalityneglectneurofilamentover 65 yearsp-taup-τpeople of colorperson centeredperson of colorphospho-tauphospho-τphosphorylated tauphysical activity interventionpilot trialpopulation of colorpost-translational modification of tauposttranslational modification of tauprimary degenerative dementiapsychologicpsychologicalracialracial backgroundracial originrandomized trialrecruitresponserisk mitigationsenile dementia of the Alzheimer typesocio-economicsocio-economicallysocioeconomicallysocioeconomicssoluble amyloid precursor proteinstrenuous activitystrenuous physical activitystudy designtautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1theoriestherapeutic efficacytherapy efficacyunder representation of groupsunder represented groupsunder represented peopleunder represented populationsunderrepresentation of groupsunderrepresented peoplevascular contributions in dementiavascular contributions to dementiavascular related dementiavigorous exercisevigorous intensityvigorous physical activityvulnerable groupvulnerable individualvulnerable peopleτ Proteinsτ phosphorylation≥65 years
Description preview
Project Summary
The average age of the U.S. population is rapidly increasing and with it the prevalence of age-associated
cognitive decline. Furthermore, the risk for age-associated cognitive decline may disproportionately affect
many historically underrepresented groups. Regular physical activity (PA) is associated with lower risk for
cognitive…
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