grant
Examining the effect of cadmium metal exposure on Alzheimer's disease genetic alleles using herpes viral infected cerebral organoids
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 15 Sept 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025(TNF)-α3-10C3-D3-Dimensional3DAD dementiaAD detectionAD pathologyAMCF-IAPOEAccelerationAffectAllelesAllelomorphsAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer disease detectionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's biomarkerAlzheimer's detectionAlzheimer's disease biological markerAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease riskAlzheimer's disease testAlzheimer's pathologyAlzheimer's patientAlzheimer's testAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinApo-EApoE proteinApolipoprotein EAstrocytesAstrocytusAstrogliaAstroproteinAutopsyAβB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BiologicalBiological MarkersCCL2CCL2 geneCCL3CCL3 geneCCL5CSIFCSIF-10CTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCXCL8CachectinCadmiumCd elementCell BodyCell Communication and SignalingCell SignalingCellsCellular Immune FunctionCerebrumChemokine (C-C Motif) Ligand 5Chemokine (C-C motif) Ligand 3Chemokine, CC Motif, Ligand 2Co-StimulatorCostimulatorCytokine Synthesis Inhibitory FactorCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneD17S136EDataDegenerative Neurologic DisordersDisease MarkerDonor ScreeningDonor SelectionELISAEPH GeneEPH Tyrosine Kinase 1 GeneEPHA1EPHA1 geneEPHTEPHT1Enzyme-Linked Immunosorbent AssayEpidermal Thymocyte Activating FactorExposure toFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryG0S19-1GCP1GFA-ProteinGFAPGene variantGenesGeneticGenetic DiseasesGenetic DiversityGenetic VariationGenomeGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinHPGFHSV-1HSV1Heavy MetalsHepatocyte-Stimulating FactorHerpes SimplexHerpes Simplex InfectionsHerpes Simplex Type 1Herpes Simplex Virus 1Herpes Simplex Virus Type 1Herpes simplex diseaseHerpesvirus 1Herpesvirus hominis diseaseHortega cellHumanHybridoma Growth FactorIFN-GammaIFN-Gamma-Inducing Factor GeneIFN-beta 2IFN-gIFN-gamma-Inducing FactorIFN-γIFNB2IFNGIFNγIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-1 alphaIL-1-aIL-10IL-17IL-17 GeneIL-17AIL-17A GeneIL-18IL-18 GeneIL-1AIL-1alphaIL-1gIL-1g GeneIL-1αIL-2IL-6IL-8IL1-AlphaIL1-αIL10IL10AIL17IL17 ProteinIL17 geneIL17AIL17A GeneIL18IL18 ProteinIL18 geneIL1A ProteinIL1F1IL1F4IL1F4 GeneIL2 ProteinIL6 ProteinIL8IL8 geneImmuneImmune InterferonImmune systemImmunesIn VitroIndividualInflammatoryInterferon GammaInterferon Type IIInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 10 PrecursorInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin 1alphaInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-1 alphaInterleukin-10Interleukin-17Interleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-2Interleukin-6Interleukine 2Interleukine 2 PrecursorInterleukine IIIntracellular Communication and SignalingK60LD78ALPHALinkLymphocyte Mitogenic FactorMCAFMCP-1MCP1MGC12320MGC12320 GeneMGC17164MGI-2MIP 1alphaMIP-1-alphaMIP-1aMIP1AMacrophage-Derived TNFMeasurementMeasuresMetal exposureMicrogliaMitogenic FactorModelingModern ManMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMonocyte-Derived TNFMyeloid Differentiation-Inducing ProteinNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuronsOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellOrganoidsPU.1 GenePathogenesisPathway interactionsPatternPhenotypePlasmacytoma Growth FactorPopulationPreinterleukin 1 AlphaPrimary Senile Degenerative DementiaProcessRANTESRNA SeqRNA sequencingRNAseqRiskRisk-associated variantRoleSCYA2SCYA3SCYA5SCYB8SIS deltaSIS-deltaSISdSPI1SPI1 geneSignal TransductionSignal Transduction SystemsSignalingSmall Inducible Cytokine A2Small Inducible Cytokine A3Small Inducible Cytokine A5Spleen Focus Forming Virus Proviral Integration Gene 1Staining methodStainsStem Cell InhibitorT cell growth factorT-Cell Growth FactorT-Cell RANTES ProteinT-Cell Specific Protein p288T-Cell Stimulating FactorTCP228TNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTREM2TREM2 geneTSG-1TestingThymocyte Stimulating FactorToxic effectToxicitiesTriggering Receptor Expressed in Myeloid Cells 2Triggering Receptor Expressed on Myeloid Cells 2Tumor Necrosis FactorTumor Necrosis Factor-alphaUrineVariantVariationViralViral DiseasesVirusVirus DiseasesWorka beta peptideabetaabeta depositionallelic variantalzheimer riskamyloid betaamyloid beta depositionamyloid β depositionamyloid-b proteinastrocytic gliaaβ depositionb-ENAPbeta amyloid fibrilbio-markersbiologicbiologic markerbiological signal transductionbiomarkerbrain tissuecell typecerebralcytokinedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesenzyme linked immunoassayexposure to metalflow cytophotometrygene networkgenetic conditiongenetic disordergenetic variantgenomic variantgitter cellherpes simplex iherpes simplex virus 1 infectionherpes simplex virus infectionherpes simplex-1iPSiPSCiPSCsimmune functionin vivo Modelinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinsightinterferon beta 2lFN-Gammalymphoblastoid cell linemesogliamicroglial cellmicrogliocytemolecular biomarkermolecular markermortalitynecropsyneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatoryneuronalnovelp-taup-τpathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseaseperivascular glial cellphospho-tauphospho-τphosphorylated taupost-translational modification of taupostmortemposttranslational modification of tauprimary degenerative dementiaprogenitor cell differentiationprogenitor differentiationrisk allelerisk generisk genotyperisk locirisk locusrisk variantsenile dementia of the Alzheimer typesocial rolesoluble amyloid precursor proteinstem and progenitor differentiationstem cell differentiationtau phosphorylationtau posttranslational modificationtau-1test for Alzheimerthree dimensionaltranscriptome sequencingtranscriptomic sequencingtranscriptomicsviral infectionvirus infectionvirus-induced diseaseτ phosphorylation
Description preview
PROJECT SUMMARY/ABSTRACT
Several genetic variants within immune system genes like APOE, TREM2, BIN1, CR1, etc have been
associated with Alzheimer’s disease (AD). There is also evidence showing heavy metals such as cadmium
(Cd) toxicity being associated with AD. Studies have shown that circulatory levels of Cd are significantly
increased in AD…
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