grant
Examining Effects of Intensive BP Control on MCI/Dementia and Plasma Biomarker Trajectories by AD Pathology: Elucidating neuroprotective effects in the racially and ethnically diverse SPRINT trial
Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 30 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY202521+ years oldA β-42A β42A-beta 42A-beta42AD dementiaAD pathologyAD related dementiaADRDAbeta-42Abeta42Active Follow-upAdultAdult HumanAffectAgeAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmmon HornAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-42Amyloid beta-ProteinAmyloid beta42Amyloid βAmyloid β-42Amyloid β-PeptideAmyloid β-ProteinAmyloid β42Amyloidβ-42Amyloidβ42AssayAstroproteinAttenuatedAβAβ-42Aβ42BP controlBP managementBioassayBiologicalBiological AssayBiological MarkersBlackBlack raceBlood PlasmaBlood PressureBlood SampleBlood VesselsBlood specimenBrainBrain Nervous SystemCessation of lifeClinicalCornu AmmonisDataData BanksDatabanksDeathDementiaDependenceDiagnosisDifferences between sexesDiffers between sexesEncephalonEpidemiologyEthnic GroupEthnic OriginEthnic PeopleEthnic PopulationEthnic individualEthnicityEthnicity PeopleEthnicity PopulationFutureGFA-ProteinGFAPGenotypeGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGroups at riskHippocampusHispanicHypertensionImmuneImmunesIncidenceInterventionIntervention TrialInterventional trialInvestigatorsLightLow PrevalenceMR ImagingMR TomographyMRIMRIsMachine LearningMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceModificationNMR ImagingNMR TomographyNerve DegenerationNeuron DegenerationNeuropsychologiesNeuropsychologyNuclear Magnetic Resonance ImagingOutcomePGF genePLGF-2ParticipantPatient SelectionPeople at riskPersonsPersons at riskPhotoradiationPlGFPlGF proteinPlacental Growth FactorPlasmaPlasma SerumPlayPopulationPopulation HeterogeneityPopulations at RiskPrimary Senile Degenerative DementiaProteinsProteomicsRaceRacesRacial GroupResearch PersonnelResearch ResourcesResearchersResourcesReticuloendothelial System, Serum, PlasmaRiskRoleSamplingSex DifferencesSexual differencesStratificationSubgroupTimeVascular Hypertensive DiseaseVascular Hypertensive DisorderVascular remodelingWhite Matter HyperintensityWorkZeugmatographya beta peptideabetaactive followupadulthoodagesamyloid betaamyloid-b proteinarmattenuateattenuatesbeta amyloid fibrilbio-markersbiologicbiologic markerbiomarkerblood pressure controlblood pressure interventionblood pressure managementcandidate biomarkercandidate markercardiac disease induced cognitive impairmentcerebrovascular contribution to cognitive impairment and dementiaclinical practicecognitive assessmentcognitive testingcompare to controlcomparing females and malescomparing women and mencomparison controldata depositorydata repositorydata set repositorydataset repositorydementia riskdisabilitydiverse populationsepidemiologicepidemiologicalethnic diversityethnic subgroupethnically diverseethnicity groupfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesfollow upfollow-upfollowed upfollowupheterogeneous populationhigh blood pressurehippocampalhyperpiesiahyperpiesishypertension treatmenthypertensive diseasehypertensive disordermachine based learningmild cognitive disordermild cognitive impairmentmortalityneural degenerationneural inflammationneurodegenerationneurodegenerativeneurofilamentneuroinflammationneuroinflammatoryneurological degenerationneuronal degenerationneuroprotectionneuroprotectiveneuropsychologicnew markernovelnovel biomarkernovel markerolder adultolder adulthoodplacenta growth factorpopulation diversityprimary degenerative dementiaproduct placenta growth factorpublic repositorypublicly accessible repositorypublicly available repositoryracialracial backgroundracial diversityracial originracial populationracial subgroupracially diverserisk factor for dementiarisk for dementiascreeningscreeningssecondary analysissenile dementia of the Alzheimer typesexsex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolesoluble amyloid precursor proteinsynergismtreatment strategytrial designvascularvascular cognitive impairment and dementiavascular contribution to impairment or dementiavascular contributions to cognition/dementiavascular contributions to cognitive decline and dementiavascular contributions to cognitive impairment and dementiavascular risk factorwomen compared to menwomen compared with menwomen versus menwomen vs. men
Description preview
ABSTRACT:
Alzheimer’s disease (AD) and AD-related dementias (AD/ADRD) are leading causes of dependence and disability in older adults, projected to impact ~153 million people worldwide by 2050. Hypertension (HTN) increases the risk of both AD and Vascular Cognitive Impairment and Dementia (VCID). Black and Hispanic adults have higher average blood…
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