grant
Examining CSF and Blood Biomarkers to Gain Insight into Postoperative Delirium and Neurocognitive Dysfunction
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2025AD dementiaAcquired brain injuryActive Follow-upAddressAffectAlbuminsAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimers DementiaAmentiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnesthesiaAnesthesia proceduresAnimalsAortaAssayAstrocytesAstrocytosisAstrocytusAstrogliaAstroproteinAβBioassayBiological AssayBiological MarkersBloodBlood - brain barrier anatomyBlood Reticuloendothelial SystemBlood SampleBlood specimenBlood-Brain BarrierBrainBrain InjuriesBrain Nervous SystemCD140b AntigensCerebrospinal FluidCharacteristicsChemotactic CytokinesCluster AnalysesCluster AnalysisCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalDeliriumDementiaDiagnosisDiseaseDisorderDisturbance in cognitionDysfunctionEarly DiagnosisEncephalonFunctional disorderFutureGFA-ProteinGFAPGlial Fibrillary Acid ProteinGlial Fibrillary Acidic ProteinGlial Intermediate Filament ProteinGoalsHemato-Encephalic BarrierHeterogeneityHomologous Chemotactic CytokinesHospital AdmissionHospitalizationHospitalsHumanImpaired cognitionIncidenceIndividualInflammationInjuryIntercrinesInvestigatorsIsoformsLightMT-bound tauMeasurableMeasurementModelingModern ManMonitorNerve CellsNerve UnitNeural CellNeurocognitiveNeurocyteNeuronal InjuryNeuronsObservation researchObservation studyObservational StudyObservational researchOperative ProceduresOperative Surgical ProceduresOutcomePDGFPDGF Receptor βPDGF beta ReceptorPDGF β ReceptorPDGFR betaPDGFR-βPathologicPathway interactionsPatientsPatternPerioperativePerioperative CarePhotoradiationPhysiopathologyPlatelet-Derived Growth FactorPlatelet-Derived Growth Factor Receptor Beta PolypeptidePlatelet-Derived Growth Factor Receptor βPlatelet-Derived Growth Factor beta ReceptorPostoperativePostoperative PeriodPrimary Senile Degenerative DementiaProtein IsoformsReportingResearchResearch PersonnelResearch ResourcesResearchersResourcesRiskSIS cytokinesSamplingSpecificityStagingSurgicalSurgical InterventionsSurgical ProcedureSyndromeTherapeuticTimea beta peptideabetaabnormal brain functionactive followupamyloid betaamyloid-b proteinastrocytic gliabeta amyloid fibrilbio-markersbiologic markerbiomarkerblood-based biomarkerblood-based markerbloodbrain barrierbrain damagebrain dysfunctionbrain impairmentbrain-injuredcerebral spinal fluidchemoattractant cytokinechemokinecognitive dysfunctioncognitive losscytokinedeliriousdysfunctional brainearly detectionfollow upfollow-upfollowed upfollowupglial activationglial cell activationhigh riskimprovedindividual responseindividualized responseinjuriesinsightmicrotubule bound taumicrotubule-bound tauneural inflammationneurofilamentneuroinflammationneuroinflammatoryneuron injuryneuronalolder adultolder adulthoodp-taup-τpathophysiologypathwayphospho-tauphospho-τphosphorylated taupost-operative deliriumpost-translational modification of taupostoperative deliriumposttranslational modification of tauprimary degenerative dementiarisk stratificationsenile dementia of the Alzheimer typesoluble amyloid precursor proteinspinal fluidstandard of carestratify risksurgerytautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1therapeutic targetτ Proteinsτ phosphorylation
Description preview
PROJECT SUMMARY/ABSTRACT
Delirium occurs in 10-40% of surgical hospitalizations and has been associated with post-discharge declines in
cognition and function, including Alzheimer’s Disease (AD). After hospital discharge, the incidence of
neurocognitive dysfunction is estimated to be up to 10-25% in the year after surgery. However, pathways…
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