grant
Exacerbation of colitis by the microbiota
Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 15 Jan 2015Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AddressAffectAlditolsAmericanAnimal ModelAnimal Models and Related StudiesAntibiotic AgentsAntibiotic DrugsAntibioticsArtificial SweetenersAutoregulationBacteriaBionomicsCarbohydratesCatabolismCausalityChildhoodChronicColiform BacilliColitisColonic inflammationD glucitolDangerousnessDataDevelopmentDietDisaccharidesDiseaseDisease ProgressionDisorderEcologyEnteric BacteriaEnterobacteriaEnterobacteriaceaeEnvironmental FactorEnvironmental Risk FactorEnzyme GeneEnzymesEquilibriumEtiologyExhibitsExposure toFat-Restricted DietFatsFatty acid glycerol estersFermentationFoodGI microbiomeGI microbiotaGammaproteobacteriaGastrointestinal microbiotaGeneticGenetic predisposing factorGlucitolGoalsHigh Fat DietHistoryHomeostasisHumanHydrogen OxideIditol DehydrogenaseImpairmentInflammationInflammatory Bowel DiseasesInflammatory Bowel DisorderIntakeIntestinalIntestinesKnowledgeL iditol dehydrogenaseL-Iditol 2-DehydrogenaseLarge IntestineLightLinkLow-Fat DietMiscellaneous AntibioticModelingModern ManMonosaccharidesNuclearOligosaccharidesOnset of illnessOralOsmosisOutcomePainPainfulPathogenesisPatientsPersonsPhotoradiationPhysiological HomeostasisPolyol DehydrogenaseProbioticsProcessProgressive DiseaseRecording of previous eventsReducing dietResearchRiskSorbitolSorbitol DehydrogenaseStressSugar AlcoholsSymptomsT-Cell ActivationTaxonTestingWaterWorkabsorptionacronymsactivate T cellsbacteria in the gutbalancebalance functionbowelbowel inflammationcausationcolon microbescolon microbial communitycolon microbiotacolonic microbiotacommunity microbesdevelopmentaldietarydietsdigestive tract microbiomedisease causationdisease onsetdisorder onsetdysbacteriosisdysbiosisdysbioticearly childhoodearly life exposureenteric microbial communityenteric microbiomeenteric microbiotaenvironmental riskexpectationfecal microbial communityfecal microbiotagamma Proteobacteriagastrointestinal microbial floragastrointestinal microbiomegastrointestinal symptomgenetic risk factorgut bacteriagut communitygut floragut inflammationgut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomehistoriesinflamed bowelinflamed coloninflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinherited factorinnovateinnovationinnovativeintestinal autoinflammationintestinal biomeintestinal floraintestinal inflammationintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloralarge bowelmicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobial imbalancemicrobiomemicrobiotamicrobiota compositionmicrofloramicroorganism communitymodel of animalmouse modelmultispecies consortiamurine modelnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypediatricpolymicrobial communitypolyolpreventpreventingsaturated dietary fatsaturated dietary lipidsaturated fatsaturated lipidwestern dietwestern-style dietwestern-type dietγ-Proteobacteria
Description preview
ABSTRACT
Inflammatory Bowel Disease (IBD) is a painful and often debilitating condition affecting millions of Americans.
There is no single cause for IBD, but the disease results from a perfect storm of genetics, diet, and antibiotic
exposures, particularly in early childhood. We know that antibiotics and processed foods, including those high in…
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