grant
Ex vivo intraoperative surgical basal margin analysis in head and neck cancer resection: clinical validation
Organization ILLINOIS INSTITUTE OF TECHNOLOGYLocation CHICAGO, UNITED STATESPosted 2 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AbscissionAcademic Medical CentersActive Follow-upAddendumAddressAdjuvantAdjuvant TherapyAnatomic SitesAnatomic structuresAnatomyAntibodiesBody TissuesCallbackCancersCell Communication and SignalingCell SignalingClinicalClinical ResearchClinical StudyClinical TrialsCollaborationsComputer SimulationComputer based SimulationDataData AnalysesData AnalysisDetectionDiagnosisDiseaseDisease-Free SurvivalDisorderEGF ReceptorEGFRERBB ProteinEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEvent-Free SurvivalExcisionExclusionExtirpationFluorescenceFreeze SectioningFrozen SectionsFutureHER1HNSCCHead and NeckHead and Neck CancerHead and Neck CarcinomaHead and Neck Squamous Cell CarcinomaHead and Neck SurgeonHead and neck structureHealthHistopathologyHomeIllinoisIlluminationImageImaging technologyIndividualIntracellular Communication and SignalingLightLightingLocationMalignant CellMalignant Head and Neck NeoplasmMalignant NeoplasmsMalignant TumorManualsMethodsMorbidityMorbidity - disease rateNetherlandsNoiseOperative ProceduresOperative Surgical ProceduresOpticsOralPathologyPatientsPattern RecognitionPerformancePhase 2 Clinical TrialsPhase II Clinical TrialsPhotoradiationPrimary NeoplasmPrimary TumorProceduresPropertyProtocolProtocols documentationPublic HealthQOLQuality of lifeRadiation therapyRadiotherapeuticsRadiotherapyReaderReconstructive Surgical ProceduresRecurrenceRecurrentRemovalResearch ResourcesResearch SpecimenResectedResourcesSCCHNSignal TransductionSignal Transduction SystemsSignalingSourceSpecificitySpecimenSpottingsSurfaceSurgeonSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSurgical marginsSurvival RateSystemTGF-alpha ReceptorTechnologyTestingTissuesTrainingTransforming Growth Factor alpha ReceptorUniversity Medical CentersUrogastrone Receptoractive followupadjuvant treatmentbiological signal transductionc-erbB-1c-erbB-1 Proteincancer cellcancer surgerychemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapyclinical relevanceclinical significanceclinical validationclinically relevantclinically significantcomputational simulationcomputerized simulationdata interpretationdesigndesigningerbB-1erbB-1 Proto-Oncogene ProteinerbBlfluorescence imagingfluorescent imagingfollow upfollow-upfollowed upfollowuphead and neck squamous carcinomahead and neck squamous cell cancerhead/neck cancerhomesimage processingimagingimaging Segmentationimaging approachimaging based approachimaging systemimprovedinnovateinnovationinnovativelenslensesmachine learned algorithmmachine learning algorithmmachine learning based algorithmmalignancymalignant head and neck tumormaxillofacialneoplasm/canceropticalphase II protocolproto-oncogene protein c-erbB-1prototyperadiation treatmentradio-chemo-therapyradio-chemotherapyradiochemotherapyreconstruction surgeryreconstructive surgeryresectionsurgerytissue processingtreatment with radiationtumor
Description preview
Ex vivo intraoperative surgical basal margin analysis in head and neck cancer resection: clinical
validation
In a clinical collaboration with the University Medical Center Groningen (UMCG), Netherlands—led by Oral and
Maxillofacial Surgeon, Dr. Witjes—we will advance and clinically test an intraoperative dual-aperture
fluorescence ratio (dAFR)…
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