grant
Evolutionary Tradeoffs in Antibiotic Resistance
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Feb 2025Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025Antibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsBacteriaBacteriophagesBiologic ModelsBiological ModelsClinicalComputer AnalysisDNA mutationDataDevelopmentEnvironmentEvolutionEyeEyeballFixationGenetic ChangeGenetic ModelsGenetic defectGenetic mutationHorizontal Gene TransferIndividualInfectionLaboratoriesLaboratory StudyLateral Gene TransferLong-term infectionMiscellaneous AntibioticMobile Genetic ElementsModel SystemModelingMutationPhagesPlasmidsPopulationPopulation GeneticsPrevalencePublic HealthResistanceResistance to antibioticsResistant to antibioticsSystems AnalysesSystems Analysisanthropogenesisanthropogenicantibiotic drug resistanceantibiotic resistance emergenceantibiotic resistantbacterial viruschronic infectioncomputational analysescomputational analysiscomputer analysescostdevelopmentalemerging antibiotic resistancefitnessgenetic resistancegenome mutationindividual patientmicrobialmutantnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenpersistent infectionpressureresistance generesistance locusresistantresistant genesample fixation
Description preview
ABSTRACT
Antibiotic resistance emerges when a mutation in a bacterium causes a previously inhibitory concentration of a
compound to become survivable. Through the accumulation of mutations conferring varying increases in
resistance, already many easy-to-treat infections have become nearly incurable, and are spreading in part
anthropogenically. The…
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