grant
Evolutionary Mechanisms of Enhanced Environmental Stress Resistance
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 19 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AgingAnimalsAvesAvianBiochemistryBiological ChemistryBiologyBirdsBlindnessCancersCell ProtectionCellular biologyCessation of lifeChronicCytoprotectionDataDeathDomestic HorseDysfunctionEquineEquine SpeciesEquus caballusEquus przewalskiiFishesFunctional disorderGenomeGoalsHIF 1HIF-1 proteinHIF1HIF1 proteinHealthHorsesHumanHypoxemiaHypoxiaHypoxicKnowledgeMalignant NeoplasmsMalignant TumorMediatingMetalsMiceMice MammalsModern ManMolecularMurineMusNatural SelectionsNeobalaenidaeOxidantsOxidative StressOxidizing AgentsOxygen DeficiencyPathway interactionsPerformancePhysiopathologyProteinsResearchResistanceReverse engineeringSightSpecialistStressSystemTechniquesVisionWhalesWorkbiological adaptation to stresscell biologycytoprotectiveelectron acceptorenvironmental stressesenvironmental stressorhuman diseasehypoxemichypoxia inducible factor 1improvedmalignancyneoplasm/cancernew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwayprogramsreaction; crisisresistantresponsestemstress responsestress; reactionstressorvision lossvisual functionvisual loss
Description preview
PROJECT SUMMARY
Cellular responses to environmental stressors (e.g., hypoxia, metals, and oxidants) are essential
to animal performance and their dysregulation is associated with blindness, cancer, and aging.
These responses are mediated by protein-level mechanisms regulating cytoprotective programs
essential to animal survival. However, the…
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