grant
Evolutionary Analysis and Comparative Genomics of Protein Superfamilies
Organization NATIONAL LIBRARY OF MEDICINELocation UNITED STATES
NIHUS FederalResearch GrantFY2025ATP HydrolysisATP phosphohydrolaseATPaseActive SitesAdenosine TriphosphataseAdoptedAnimalsAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsApoptosisApoptosis PathwayAssayAttenuatedB burgdorferiB. burgdorferiBacteriaBacterial Gene ProductsBacterial Gene ProteinsBacterial ProteinsBindingBinding SitesBioassayBiochemicalBiogenesisBiologicalBiological AssayBiological FunctionBiological ProcessBiologyBiotechBiotechnologyBorrelia burgdorferiBorrelia burgdorferi sensu strictoBorreliella burgdorferiCRISPRCRISPR/Cas systemCatalytic RNACationsCell BodyCell LocomotionCell MigrationCell MovementCell WallCell divisionCellsCellular Immune FunctionCellular MigrationCellular MotilityCellularityClustered Regularly Interspaced Short Palindromic RepeatsCognitive DiscriminationCollaborationsCombining SiteComplexComputer AnalysisConflictConflict (Psychology)Conserved SequenceCryo-electron MicroscopyCryoelectron MicroscopyCysteineCytoplasmDNA HelicasesDNA Unwinding ProteinsDNA unwinding enzymeDimerizationDiscriminationDistantE coliE. coliElectron CryomicroscopyElementsEnvironmentEnzyme GeneEnzymesEpsilonproteobacteriaEscherichia coliEukaryotaEukaryoteFamilyFilamentFirmicutesFlagellaFutureGTP PhosphohydrolasesGTPasesGene ExpressionGeneHomologGeneralized GrowthGenesGenetic ScreeningGenetics-MutagenesisGenomeGrowthGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHE proteinHalf-CystineHomologHomologous GeneHomologueHospital InfectionsHospital acquired infectionImmuneImmune systemImmunesImmunityInfectionInflammationInnate ImmunityIntracellular Second MessengerIonsIxodesIxodes tickL-CysteineLateralLifeLinkLipidsLogicLyme BorreliosisLyme DiseaseLyme Disease SpirocheteMagnesiumMembraneMessenger RNAMg elementMiceMice MammalsMicroscopicMicrotubule StabilizationMiscellaneous AntibioticModelingModificationMolecularMolecular InteractionMotilityMovementMurineMusMutagenesisMutagenesis Molecular BiologyN-terminalNH2-terminalNICHDNTPaseNational Institute of Child Health and Human DevelopmentNational Institutes of HealthNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNosocomial InfectionsNucleic AcidsNucleoside Triphosphate PhosphohydrolaseNucleosidetriphosphataseNucleotidesOrder SpirochaetalesOrigin of LifePathogenesisPathway interactionsPeptide DomainPlayProgrammed Cell DeathProtein DimerizationProtein DomainsProtein FamilyProteinsProteobacteriaPurple BacteriaRNA HelicaseRNA-Binding ProteinsReactive SiteReagentResearchResistance to antibioticsResistant to antibioticsResolutionRibosomesRibozymesRoleS aureusS. aureusSecond Messenger SystemsSecond MessengersShapesSideSiteSpirochaetalesSpirochetesStaph aureusStaphylococcus aureusStructural ProteinStructureSystemSystems BiologyTailTertiary Protein StructureTestingTissue GrowthToxinTreesTubulinUnited States National Institutes of HealthUniversitiesViralViral ActivityViral FunctionViral PhysiologyVirulenceVirusWhole OrganismWorkantibiotic drug resistanceantibiotic resistantattenuateattenuatesbasal bodybiologicbody movementcell motilitychemical geneticscomparative genomicscomputational analysescomputational analysiscomputer analysescryo-EMcryoEMcryogenic electron microscopydimerentire genomeenzooticepsilon Proteobacteriafull genomegenetic informationgenome editinggenomic editingguanosinetriphosphatasehelicaseimmune functionimmunogenicinsightinstitutional infectionkinetosomelyme spirochetemRNAmembermembrane structuremonomernovelnucleoside triphosphataseontogenypalmitoylationpathogenpathwayrecruitreplicatorresistance strainresistant strainresolutionsrestriction enzymerestriction enzymessignal transduction second messengerssocial rolesyntacticsyntaxtreatment strategyuptakewhole genome
Description preview
The systematic analysis and discovery of biological conflict systems have been a major focus of research in the Aravind lab. Biological replicators, from genes within a genome to whole organisms, are locked in conflicts. Comparative genomics has revealed a staggering diversity of molecular armaments and mechanisms regulating their deployment,…
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