grant
Evolution of heat tolerance and drug resistance in Cryptococcus
Organization UNIVERSITY OF GEORGIALocation ATHENS, UNITED STATESPosted 12 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AIDS/HIVAccidentsAddressAffectAfricaAgricultureAllelesAllelomorphsAnimalsAssayAzole resistanceAzole resistantAzolesBioassayBiological AssayBody TemperatureC neoformansC. neoformansCessation of lifeClinicalCollectionCommunitiesComplex Genetic TraitCryptococcusCryptococcus neoformansDeathDevelopmentDiploidDiploidyDiseaseDisorderDrug resistanceDrugsEnvironmentEpistasisEpistatic DeviationEvolutionExposure toFluconazole resistanceFluconazole resistantFungal Drug ResistanceFungus DiseasesFungus drug resistantFutureGeneralized GrowthGenesGeneticGenetic DiversityGenetic EpistasisGenetic VariationGenetics-MutagenesisGenomeGlobal WarmingGoalsGrowthHIV/AIDSHigh temperature of physical objectHumanHuman ActivitiesHuman FigureHuman bodyImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunosuppressed HostIndividualInfectionInteraction DeviationInterventionLeadLibrariesMammaliaMammalsMapsMedicationMicrobeModelingModern ManModernizationMutagenesisMutagenesis Molecular BiologyMycosesNGS MethodNGS systemPathogenesisPathogenicityPb elementPharmaceutical PreparationsPhenotypePlantsPopulationPredispositionProcessResearchResistance to FluconazoleSourceSusceptibilityTechniquesTemperatureTestingTherapeutic FungicidesTimeTissue GrowthTorulaTreatment outcomeVariantVariationVirulenceVirulentWorkanti-fungalanti-fungal agentsanti-fungal druganti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantclimate changeclimatic changesdensitydevelopmentaldrug resistantdrug/agentepistatic interactionepistatic relationshipexperimentexperimental researchexperimental studyexperimentsfitnessfungal infectionfungal pathogenfungi pathogenfungusfungus drug resistancefungus infectiongene x gene interactiongenetic approachgenetic architecturegenetic epistasesgenetic strategygenome scalegenome-widegenomewideglobal climate changeglobal temperatureheavy metal Pbheavy metal leadhigh temperaturehuman diseasehuman mortalityhuman pathogenimmunosuppressed patientimproved outcomemutantnext gen sequencingnext generation sequencingnextgen sequencingnovelontogenypathogenpathogenic funguspressureprogramsresistance mutationresistance to Drugresistance to anti-fungalresistance to azoleresistant mutationresistant to Drugresistant to anti-fungalresistant to azoleresistant to fluconazoletooltraittranscriptional reprogramming
Description preview
Project Summary
Environmental microbes are affected by and evolve to succeed in the changing environments they inhabit. As
a result, changes in the environment can select for microbes that are more or less capable of causing human
infections. Cryptococcus is a genus of opportunistic fungal pathogens that cause approximately 200,000
deaths in…
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