grant
Evolution of autoreactive GC and epitope spreading in lupus
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 13 Jul 2018Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025Adoptive TransferAffinityAntibody-Secreting CellsAntigenic DeterminantsAntigensAutoantibodiesAutoantigensAutoimmune DiseasesAutoimmune StatusAutoimmunityAutologous AntigensAutomobile DrivingB blood cellsB cellB cellsB-Cell DeficiencyB-CellsB-LymphocytesB-cellBinding DeterminantsC3d ReceptorsCD 21 AntigensCD11CD11 AntigensCD11cCD183CD21CD21 AntigensCKR-L2CMKAR3CR2CR2 ReceptorsCXCR3CXCR3 geneCell BodyCell surfaceCellsChemokine (C-X-C Motif) Receptor 3ChimeraChimera organismClone CellsComplement 3d ReceptorsComplement ReceptorComplement Receptors 2DevelopmentDiseaseDisorderEffector CellEnvironmentEpitope spreadingEpitopesEpstein-Barr Virus ReceptorsEventEvolutionG Protein-Coupled Receptor 9GPR9GeneticGerminal CenterHealthIP10IP10 ReceptorIP10-Mig receptorIP10-RITGAXITGAX geneImmunoglobulin-Secreting CellsKineticsLongitudinal StudiesLupusLupus Erythematosus DisseminatusLymphoidMalpighian corpusclesMediatingMiceMice MammalsMig ReceptorMig-RMigRModelingMurineMusNuclear AntigensPathogenesisPathologyPatientsPeptidesPhenotypePopulationRegulationReportingRoleSLESelf-AntigensSiteSpecificitySplenic White PulpStructure of germinal center of lymph nodeSystemic Lupus ErythematosusSystemic Lupus ErythematousSystemic Lupus ErythmatosusT-CellsT-LymphocyteTestingTimeWhite Pulpantigen spreadingautoimmune antibodyautoimmune conditionautoimmune disorderautoimmune reactivityautoimmunity diseaseautoreactive B cellautoreactive antibodyautoreactivitychimerasdevelopmentaldisseminated lupus erythematosusdrivinghumoral immunity deficiencyimmunogenlong-term studylongitudinal outcome studiesmigrationmouse modelmurine modelmutantnovelpathogenic autoantibodiesresponseself reactive B cellself reactive antibodysocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicssystemic lupus erythematosisthymus derived lymphocyte
Description preview
Systemic lupus erythematosus (SLE) is an incurable autoimmune disease and represents a substantial health problem in the population. Longitudinal studies of patients and murine models of SLE identify development of autoantibodies against new epitopes over time that correlate with increased pathology. The phenomena is referred to as epitope…
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