grant
Evidence For Endothelial Involvement in Idiopathic Nephrotic Syndrome: A Role for CD93
Organization RESEARCH INST NATIONWIDE CHILDREN'S HOSPLocation COLUMBUS, UNITED STATESPosted 1 Jul 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20260-11 years old22kD Caveolae ProteinAdriablastinAdriablastineAdriacinAdriamycin PFSAdriamycin RDSAdriblastinAdriblastinaAdriblastineAdrimedacAdvisory CommitteesAffectAgeAnimal ModelAnimal Models and Related StudiesAntibodiesAutoantibodiesBindingBiologicalBiological FunctionBiological MarkersBiological ProcessBiologyBlood SerumBlood VesselsBlood capillariesCausalityCaveolin 1, Caveolae Protein, 22kDCell BodyCell CoatCell Communication and SignalingCell Culture TechniquesCell LineCell SignalingCell surfaceCellLineCellsCellular injuryChildChild YouthChildhoodChildren (0-21)CicatrixCirculationClinicalClinical ResearchClinical StudyCo-cultureCocultivationCocultureCoculture TechniquesDOXO-CELLDataDevelopmentDevelopment PlansDiseaseDisease ProgressionDisease remissionDisorderDoseDoxolemDoxorubinElectron MicroscopyEndothelial CellsEndotheliumEtiologyExperimental ModelsFSGSFarmiblastinaFocal Adhesion Kinase 1Focal and Segmental GlomerulosclerosisFocal segmental glomerular sclerosisFoot ProcessGenesGlomerular diseaseGlycocalyxGoalsHeparan SulfateHeparitin SulfateHeterogeneityHistologicHistologicallyHumanImmunosuppressantsImmunosuppressive AgentsImmunosuppressive drugImmunosuppressive treatmentIn VitroInjuryIntegrinsIntegrins Extracellular MatrixIntracellular Communication and SignalingInvestigatorsKidneyKidney DiseasesKidney FailureKidney InsufficiencyKidney Urinary SystemLeadershipLiposomal AdriamycinMediatingMediatorMentorsMethodologyModelingModern ManMolecular InteractionNPHS1 gene productNephropathyNephrotic SyndromeOutcomePTK2 Protein Tyrosine Kinase 2PathogenesisPathway interactionsPatientsPatternPedicelPilot ProjectsPopulationProteinsProteinuriaPuromicinaPuromycinPuromycinePuromycinumRecombinantsRecurrent diseaseRelapseRelapsed DiseaseRemissionRenal CellRenal DiseaseRenal FailureRenal Glomerular Diseases and SyndromesRenal InsufficiencyRenal functionRenal glomerular diseaseRenal glomerular disease or syndromeRenal glomerular disorderRenal glomerular syndromeReportingResearch PersonnelResearchersRoleRubexScarsSerumSignal TransductionSignal Transduction SystemsSignalingSourceSpecificityStrains Cell LinesSurrogate MarkersSystemTask ForcesTerminologyTestingThrombomodulinTimeTrainingUrineVIP21VIP21 proteinVisceral Epithelial CellWorkadriamycinadvisory teamagesauthorityautoimmune antibodyautoreactive antibodybio-markersbiologicbiologic markerbiological signal transductionbiomarkercapillarycareercareer developmentcausationcaveolin 1cell culturecell culturescell damagecell injurycell typecellular damageclinical relevanceclinically relevantcultured cell linedamage to cellsdevelopmentaldisease causationendogenous substrate pp120experiencefocal adhesion kinasefocal adhesion protein tyrosine kinasefocal adhesion-associated protein tyrosine kinase pp125FAKglomerular endotheliumglomerular visceral epithelial cellimmune suppressive agentimmune suppressorimmunosuppressive substanceimmunosuppressorin vivoinjuriesinjury to cellsinnovateinnovationinnovativekidney biopsykidney cellkidney disorderkidney functionkidsmodel of animalnephrinnoveloverexpressoverexpressionpathwaypediatricpharmacologicpilot studypodocyteprecision medicineprecision-based medicinepredict clinical outcomepredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreventpreventingprognosticrenalrenal biopsyrenal disorderresponse to therapyresponse to treatmentself reactive antibodyside effectsocial rolesurrogate bio-markerssurrogate biomarkerssyndecantargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapeutic targettherapy responsetranscriptomicstreatment responsetreatment responsivenessurinaryvascularvesicular integral membrane protein 21 kDayoungster
Description preview
Project Summary/Abstract: Idiopathic Nephrotic Syndrome (INS) is the most common type of nephrotic
syndrome in childhood, yet its cause remains unknown. Most authorities consider the disease to be mediated
by an unknown circulating factor that directly binds the podocyte, causing podocyte activation and proteinuria.
However, our group has shown…
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