grant

Evaluation of Long Acting Injectable (LAI) and Teen clubs in adolescents (ATTUNE)

Organization KWAZULU-NATAL RESEARCH INSTITUTE TB-HIVLocation Durban, SOUTH AFRICAPosted 24 Sept 2023Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20250-11 years old12-20 years oldAIDS VirusAIDS preventionAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive Follow-upAddressAdherenceAdolescenceAdolescentAdolescent HIVAdolescent YouthAdoptionAfrica South of the SaharaAgeAssess implementationBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentCaringCessation of lifeChildChild YouthChildhoodChildren (0-21)ClinicClinicalClinical TrialsClinical Trials DesignCohort StudiesComplexConcurrent StudiesConditioning TherapyConflictConflict (Psychology)Continuity of CareContinuity of Patient CareContinuum of CareCountryDeathDeath RateDoseDrugsEconomic IncomeEconomical IncomeEffectivenessEnrollmentEvaluationFailureFatigueFeedbackFriendsFundingHIVHIV PreventionHIV infection in adolescenceHIV infections in adolescentsHIV-infected (HIV+) adolescentsHIV-infected adolescentsHIV/AIDS preventionHuman Immunodeficiency VirusesImplementation assessmentImprove AccessIncomeIndividualInjectableInternationalInterventionInvestigatorsLAV-HTLV-IIILack of EnergyLow-resource areaLow-resource communityLow-resource environmentLow-resource regionLow-resource settingLymphadenopathy-Associated VirusMaintenanceMeasuresMedicationNational Institutes of HealthOralOutcomePerinatalPeripartumPersonsPharmaceutical PreparationsPreparednessPrincipal InvestigatorProceduresProtocolProtocols documentationPublishingRE-AIMRandomizedRandomized, Controlled TrialsReach, Effectiveness, Adoption, Implementation, and MaintenanceReadinessRecommendationResearchResearch PersonnelResearchersResource-constrained areaResource-constrained communityResource-constrained environmentResource-constrained regionResource-constrained settingResource-limited areaResource-limited communityResource-limited environmentResource-limited regionResource-limited settingResource-poor areaResource-poor communityResource-poor environmentResource-poor regionResource-poor settingRuralSchoolsServicesShameSocial supportSouth AfricaSub-Saharan AfricaSubsaharan AfricaSupervisionTeenTeenagersTrainingUnited States National Institutes of HealthViralViral BurdenViral LoadViral Load resultVirus-HIVVisitYouthYouth 10-21active followupadolescence (12-20)adolescents living with HIVadolescents with HIVagesantiretroviral therapyantiretroviral treatmentassess effectivenessbehavior interventionbehavioral interventionclinical implementationcostdesigndesigningdetermine effectivenessdrug/agenteffectiveness assessmenteffectiveness evaluationeffectiveness measureeffectiveness/implementation designeffectiveness/implementation hybrid designenrollevaluate effectivenessevaluate implementationevaluation of implementationexamine effectivenessexperiencefollow upfollow-upfollowed upfollowupforgettingimplementation determinantsimplementation evaluationimplementation factorsimplementation measuresimplementation scienceimplementation strategyimprovedimproved outcomeincomesinnovateinnovationinnovativejuvenilejuvenile humankidsm-HealthmHealthmHealth therapeuticmHealth therapymHealth treatmentmedication administrationmeetingmeetingsmhealth interventionsmobile healthmobile health interventionmobile health therapeuticmobile health therapymobile health treatmentmortality ratemortality ratioolder adultolder adulthoodpediatricpediatric HIVpediatric human immunodeficiency viruspeerperi-urbanperiurbanpillprimary outcomepublic health relevancerandomisationrandomizationrandomized control trialrandomized, clinical trialsrandomly assignedreach, efficacy, adoption, implementation, and maintenancerural arearural locationrural regionscale upside effectsocialsocial stigmasocial support networkstandard carestandard of carestandard treatmentstigmastrategies for implementationteen yearsteenageuptakeurban areaurban locationurban regionyoungsteryouth age
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PROJECT SUMMARY
Significance: South Africa has the highest number of adolescents living with HIV in the world with increasing

numbers expected to continue. However, adolescents living with HIV in South Africa have poor outcomes along

each step of the HIV continuum of care. The use of adolescent-friendly services and peer navigation can be

used to…

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