grant
Evaluating human T cells specific for Mycobacterium tuberculosis antigens that are processed and presented by infected macrophages
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025Active Follow-upAddressAllelesAllelomorphsAlveolarAlveolar MacrophagesAnimal ModelAnimal Models and Related StudiesAntigen PresentationAntigen TargetingAntigensAssayAttenuatedBCG VaccineBacille Calmette Guerin vaccineBacillus Calmette Guerin VaccineBacillus Calmette-Guérin vaccineBioassayBiological AssayBlood monocyteBronchioalveolar LavageBronchoalveolar LavageBronchopulmonary LavageCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell IsolationCell SegregationCell SeparationCell Separation TechnologyCellsCessation of lifeCirculationClinicalClonal ExpansionCommunicable DiseasesDataDeathDiseaseDisorderEnrollmentExposure toGeneralized GrowthGrowthHouseholdHumanImmuneImmune responseImmunesImmunityIndividualInfectionInfectious DiseasesInfectious DisorderInvestigationKineticsKnowledgeLinkLong-term cohortLongitudinal StudiesLongitudinal cohortLungLung LavageLung Respiratory SystemLung TBLung TuberculosisM tbM tuberculosisM tuberculosis antigenM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis antigenM. tuberculosis infectionM.tb antigenM.tb infectionM.tuberculosis infectionMHC ReceptorMTB infectionMTB vaccineMacrophageMajor Histocompatibility Complex ReceptorMapsMarrow monocyteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisModern ManMtb antigenMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis antigensMycobacterium tuberculosis infectionMφOutcomePeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPeptidesPersonsPhagosomesPhenotypeProcessProteinsPulmonary MacrophagesPulmonary TBPulmonary TuberculosisR-Series Research ProjectsR01 MechanismR01 ProgramResearch GrantsResearch Project GrantsResearch ProjectsSamplingSpecificityT cell responseT-Cell Antigen Receptor SpecificityT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell Receptor SpecificityT-CellsT-LymphocyteT4 CellsT4 LymphocytesTB infectionTB vaccineTestingTimeTissue GrowthTuberculosisTuberculosis VaccinesUgandaVaccine DesignVaccine for TBVaccine for TuberculosisVaccinesVariantVariationactive followupanalyzing longitudinalanti-TB vaccineantigen-specific T cellsattenuateattenuatesbronchiolar alveolar lavagebronchopulmonary lavage therapycell sortingcohortdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedisseminated TBdisseminated tuberculosisenrollfollow upfollow-upfollowed upfollowupgain of functionhost responseimmune system responseimmunogenimmunoresponseinfection due to Mycobacterium tuberculosisinsightlatent infectionlong-term studylongitudinal analysislongitudinal outcome studiesmodel of animalmonocytemtbontogenypMHCpathogenperipheral bloodpreventpreventingpulmonaryresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingthymus derived lymphocytetuberculosis infectiontuberculous spondyloarthropathyvaccine against M. tuberculosisvaccine against Mtbvaccine against Mycobacterium tuberculosisvaccine against TBvaccine against tuberculosisvaccine candidates against tuberculosisvaccine development
Description preview
We have only a basic understanding of how variation in human T cell responses elicited after Mycobacterium
tuberculosis (Mtb) exposure and infection are linked to clinical outcomes. Emerging data in animal models and
humans demonstrate that direct T cell recognition of Mtb-infected macrophages, the niche cell for Mtb infection,
is central to a…
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