grant
Ethanol and mGluR2 signaling
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 20 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20253-hydroxy-3-methylglutaryl-CoA3-hydroxy-3-methylglutaryl-coenzyme AAblationAbscissionAbsolute ethanolAccelerationAffectAffective DisordersAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAnimalsAttenuatedBehaviorBehavioralBindingBody TissuesBrainBrain Nervous SystemBrain regionCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell Communication and SignalingCell SignalingCholesterolCholesterol HomeostasisChronicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCommon Rat StrainsDataDehydrogenasesDensity Gradient CentrifugationDensity Gradient FractionationDependenceETOHElectrophysiologyElectrophysiology (science)EncephalonEnzyme GeneEnzymesEtOH drinkingEtOH useEthanolEthanol dependenceEthyl AlcoholExcisionExtirpationG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGenesGlutamatesGrain AlcoholGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsHMG-CoAImpairmentIntracellular Communication and SignalingKnowledgeL-GlutamateLearningLentiviral VectorLentivirus VectorMeasuresMediatingMembraneMethylcarbinolMicrodialysisMolecularMolecular InteractionMolecular TargetMonitorMood DisordersNIAAANational Institute on Alcohol Abuse and AlcoholismNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurobiologyNeurocyteNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyOxidoreductaseOxidoreductase GenePatientsPrefrontal CortexRatRats MammalsRattusReductasesRemovalReportingResearchRodent ModelSaccharoseSignal TransductionSignal Transduction SystemsSignalingStrategic PlanningSucroseSurgical RemovalSynapsesSynapticTestingTherapeutic InterventionTissuesTransmissionalcohol abuse therapyalcohol abuse treatmentalcohol behavioralcohol co-morbidityalcohol comorbidityalcohol exposedalcohol exposurealcohol induced behavioralcohol ingestionalcohol intakealcohol product usealcohol related behavioralcohol treatmentalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakeanxiety-like behaviorattenuateattenuatesaxon signalingaxon-glial signalingaxonal signalingbehavior measurementbehavioral measurebehavioral measurementbiological signal transductioncholesterol metabolismdensity gradient ultracentrifugationelectrophysiologicalethanol addictionethanol behaviorethanol consumptionethanol dependencyethanol dependentethanol drinkingethanol exposedethanol exposureethanol induced behaviorethanol ingestionethanol intakeethanol product useethanol related behaviorethanol useethanol use disorderexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolextracellularglia signalingglial signalingglutamatergichydroxymethylglutaryl-CoAimprovedinnovateinnovationinnovativeintervention therapymGluR2membrane structuremetabotropic glutamate receptor 2nerve signalingneuralneural signalingneurobiologicalneuronalneuronal excitabilityneuronal signalingneurophysiologicalneurophysiologyneurotransmissionnovelpostsynapticpresynapticpreventpreventingprotein activationresectionsegregationsynapsetooltransmission process
Description preview
Project Summary
Current NIAAA strategic plan calls for efforts to identify novel molecular actions of alcohol and new remedies to
mitigate alcohol-impacted brain regions. Ever-changing research tools have exponentially accelerated our
understanding of brain regions and circuits affected by alcohol use and comorbid affective disorders. However,…
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