grant
Estradiol signaling pathways mediating sex differences in striatal synaptic plasticity
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AccelerationAffectAllelism TestAnimalsAquadiolBehaviorBehavioralBrainBrain Nervous SystemCell BodyCell Communication and SignalingCell SignalingCellsCocaineComplementation TestComputer ModelsComputerized ModelsCorpus StriatumCorpus striatum structureDataDecrease health disparitiesDifferences between sexesDiffers between sexesDimenformonDiogynDiogynetsDisparitiesDisparityDopamineDorsalDrugsERK MAP KinasesERalphaERαESR1ESR1 geneElectrophysiologyElectrophysiology (science)EncephalonEstraceEstradiolEstradiol Receptor alphaEstradiol Receptor αEstradiol ReceptorsEstradiol-17 betaEstradiol-17betaEstraldineEstrogen Receptor 1Estrogen Receptor alphaEstrogen Receptor αEstrusExtracellular Signal Regulated KinasesExtracellular Signal-Regulated MAP KinasesFeedbackFemaleFoundationsFutureGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGenetic Complementation TestGoalsGonadal Steroid HormonesHealth disparity mitigationHealth disparity reductionHydroxytyramineImpairmentIntracellular Communication and SignalingInvestigationKinasesLearningLinkLong-Term PotentiationLower health disparitiesMAPK ERK KinasesMediatingMedicationMetabotropic Glutamate ReceptorsMethodsMiceMice MammalsMitigate health disparitiesModelingMolecularMurineMusNR3A1Nerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyOvocyclinOvocylinPathway interactionsPharmaceutical PreparationsPhosphotransferase GenePhosphotransferasesPlayPopulationProgynonProteinsProtocolProtocols documentationPublishingRNA-seq using translating ribosome affinity purificationReduce health disparitiesResearchRewardsRodentRodentiaRodents MammalsRoleSalineSaline SolutionSelf AdministeredSelf AdministrationSex DifferencesSex HormonesSex Steroid HormonesSexual differencesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSliceSpecificityStriate BodyStriatumSubstance Use DisorderSynaptic plasticityTRAP RNA sequencingTRAP RNA-seqTRAP-seqTechniquesTechnologyTestingTherapeutic EstradiolThreonine/Tyrosine Protein KinaseTimeTrans TestTranscript Expression AnalysesTranscript Expression AnalysisTransgenic MiceTransgenic OrganismsTranslating Ribosome Affinity Purification followed by RNA sequencingTranslating Ribosome Affinity Purification technology followed by RNA sequencingTransphosphorylasesWhole-Cell RecordingsWorkaddictionaddictive disorderanalyze gene expressionbiological signal transductioncell typecocaine behaviorcocaine motivated behaviorscocaine related behaviorscocaine self-administrationcocaine usecocaine-associated behaviorscomplementation analysiscomplementation approachcomputational modelingcomputational modelscomputer based modelscomputerized modelingdata-driven modeldisparity in healthdrug/agentelectrophysiologicalestrousexperimentexperimental researchexperimental studyexperimentsextracellularextracellular signal related kinasefemale sex hormonefemale treatmentgender differencegender-associated differencegene expression analysisgene expression assaygene interactiongonadal steroidshabit learninghealth disparityimprovedinnovateinnovationinnovativemaleneuronalnovelpathwaysNuc-Seqself-administer cocainesensorsex based differencessex steroidsex-dependent differencessex-related differencessex-specific differencessingle moleculesingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstemstriatalsubstance usesubstance use and disordersubstance usingtranscriptional profilingtransgenictranslating ribosome affinity purification and RNA-sequencingtranslating ribosome affinity purification with RNA sequencingtreat femalestreat womentreatment among femalestreatment among womentreatment in femalestreatment in womenwomen's treatment♀♂
Description preview
Substance use disorders affect ~15% of the population, with gender differences in all stages of substance use.
Female sex-steroid hormones explain some of the disparity, such as accelerated transition from casual use to
addiction, as estradiol produces sex-specific differences in rodent learning and cocaine self-administration.
Prolonged cocaine…
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