grant
Establishing the neuropathologic and molecular features of a spontaneous canine model of peripheral neuropathy
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 15 Jan 2025Deadline 14 Jan 2031
NIHUS FederalResearch GrantFY2026ActinsAffectAgingAnimal ModelAnimal Models and Related StudiesArchitectureAutoregulationAwardAxonAxonal TransportAxoplasmic TransportBackBioinformaticsCDHF15CDHR10Cadherin-related family member 10CadherinsCandidate Disease GeneCandidate GeneCanine DiseasesCanine SpeciesCanis familiarisCell BodyCellsCellular MatrixCellular biologyChemotherapy-induced peripheral neuropathyClassificationClinicalClinical TrialsCommunicationCytoskeletal SystemCytoskeletonDNA Molecular BiologyDataDegenerative Neurologic DisordersDeteriorationDevelopmentDiseaseDisorderDoctor of PhilosophyDog DiseasesDogsDogs MammalsDorsumDysfunctionElectrophysiologyElectrophysiology (science)Engineering / ArchitectureEnvironmentFAT Atypical cadherin 3FAT tumor suppressor homolog 3 (Drosophila)FAT3FAT3 geneFDA approvedFibroblastsFoot DeformitiesFoundationsFunctional disorderFutureGenesGenomicsGoalsHearing LossHereditaryHomeostasisHumanHypoacusesHypoacusisInheritedInvestigationKIAA1989KnowledgeLaboratoriesLabradorLaryngeal ParalysisLengthLinkMaintenanceManuscriptsMetabolicMethodsModelingModern ManMolecularMolecular BiologyMorphologyMotorMotor CellMotor NeuronsMuscle WeaknessMuscular WeaknessMyoneural JunctionNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic Degenerative ConditionsNeurologicalNeuromuscular JunctionNeuron DegenerationNeurophysiology / ElectrophysiologyOperative ProceduresOperative Surgical ProceduresOutcome StudyPNS DiseasesPathologicPathway interactionsPatientsPeripheralPeripheral Nerve DiseasesPeripheral NervesPeripheral Nervous SystemPeripheral Nervous System DiseasesPeripheral Nervous System DisordersPeripheral NeuropathyPh D studentPh D. studentPh. D. studentPh.D studentPh.D.Ph.D. studentPhDPhD studentPhD. studentPhenotypePhysiological HomeostasisPhysiopathologyPreparationProteinsResearchResearch ResourcesResearch TechnicsResearch TechniquesResourcesRodent ModelRoleScienceScientistSensorySightSolidSurgicalSurgical InterventionsSurgical ProcedureSystematicsTestingTrainingTranslational ResearchTranslational ScienceUniversitiesVariantVariationVeterinary MedicineVeterinary SchoolsVisionWisconsinWorkaxonal degenerationaxonopathybench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicecaninecanine animal modelcanine modelcell biologyclinical trainingcomparativedegenerative axondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelop therapydevelopmentaldoctoral studentdog modeldomestic dogdysfunctional hearingelectrophysiologicalexperiencefundamental researchhearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmenthuman diseasehuman modelinnovateinnovationinnovativeinsightintervention developmentintracellular skeletonmodel of animalmodel of humanmotoneuronneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronal degenerationneuropathologicneuropathologicalneuropathologynovelpathophysiologypathwaypre-clinical trialpreclinical trialpreparationsprogramsresponsible research conductskillssocial rolesurgerytherapy developmenttranscriptomicstranslation researchtranslational investigationtreatment developmenttreatment trialvisual function
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PROJECT SUMMARY/ABSTRACT
Hereditary peripheral neuropathies (HPNs) are common disorders that involve degeneration of nerves in the
peripheral nervous system. Common clinical signs include progressive muscle weakness, foot deformities, and
sensory deficits. There are no FDA-approved treatments for HPNs. Spontaneous large animal models of…
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