grant
Establishing the impact of roseolovirues on development of autoimmunity due to loss of central tolerance
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAgeAntigensAssayAtrophicAtrophyAutoantibodiesAutoantigensAutoimmune DiseasesAutoimmune RegulatorAutoimmune StatusAutoimmunityAutologous AntigensAwardBioassayBiological AssayBody TissuesBystander EffectCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCausalityCell CountCell Culture TechniquesCell FunctionCell NumberCell PhysiologyCell ProcessCellular FunctionCellular PhysiologyCellular ProcessChildhoodChronicClinicalComparative StudyDataDevelopmentEtiologyExanthemExanthemaExanthema SubitumFeverFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFundingFutureGastric Parietal CellsGene ExpressionGenesGoalsHBLVHHV-6HHV-7HHV6HerpesviridaeHerpesvirusesHigh PrevalenceHumanHuman B-Lymphotropic VirusHuman CharacteristicsHuman Herpesvirus 6Human Herpesvirus 7Human NatureImmune ToleranceImmune systemImmunologic ToleranceImmunologyIn VitroInfectionInflammationK ATPaseK-AwardsK-Series Research Career ProgramsKineticsKnowledgeLaboratoriesLifeLineage TracingLinkMediatingMentorsMiceMice MammalsModelingModern ManMolecular MimicryMouse StrainsMurineMusNatureNeonatalOrganOxyntic CellsParietal CellPeriodicalsPeripheralPersonsPhysiciansProcessProductionProteinsPyrexiaR-Series Research ProjectsR01 MechanismR01 ProgramRNA SeqRNA sequencingRNAseqRashRegulatory T-LymphocyteResearchResearch Career ProgramResearch GrantsResearch Project GrantsResearch ProjectsResolutionRheumatologyRoleRoseolaRoseola InfantumRoseolovirusRoseolovirus InfectionsScientistSelf-AntigensSeroprevalencesSixth DiseaseSkin RashSortingStomachSubcellular ProcessT cell receptor repertoire sequencingT cell receptor sequencingT-Cell DepletionT-Cell DevelopmentT-Cell OntogenyT-CellsT-LymphocyteT-Lymphocyte DevelopmentT-cell depletion therapyT-cell receptor repertoireT-lymphocyte depletion therapyT4 CellsT4 LymphocytesTCR repertoireTCR repertoire sequencingTCR sequencingTCR-seqTCRseqThymic epithelial cellThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTimeTissuesTregViralViral DiseasesVirusVirus DiseasesVirus ReplicationVirus-HHV6Wild Type Mouseacute infectionadulthoodagesautoimmune antibodyautoimmune conditionautoimmune disorderautoimmune gastritisautoimmune reactivityautoimmunity diseaseautoreactive T cellautoreactive antibodyautoreactivitycareercareer developmentcausationcell culturecell culturescell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingcentral tolerancedevelopmentaldisease causationexperimentexperimental researchexperimental studyexperimentsfebrilefebrisflow cytophotometrygastricglobal gene expressionglobal transcription profileherpes virusherpesvirus 7immune system toleranceimmune unresponsivenessimmunogenimmunological paralysisin vivoinfected neonateinfected newborninsightlatent infectionneonatal infectionnewborn infectionnovelpathogenpediatricperiodicperiodicalpotassium ATPaseregulatory T-cellsresolutionsscRNA sequencingscRNA-seqself reactive antibodyself-reactive T cellsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolethymocytethymus derived lymphocytetime usetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicsviral infectionviral multiplicationviral replicationvirus infectionvirus multiplicationvirus-induced diseasewildtype mouse
Description preview
Project Summary
Murine roseolovirus (MRV) is a beta-herpesvirus that is genetically highly related to the human roseoloviruses,
HHV-6 and HHV-7. The human roseoloviruses have been associated with autoimmune disease but
demonstrating causality is confounded by the ubiquitous and chronic nature of roseolovirus infections. We have
shown that neonatal…
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