grant
Establishing the dynamics of lymphoid clonal hematopoiesis and its aging-related disease consequences
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 1 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Aberrant ChromosomeAddressAffectAgeAgingAllelic LossAreaB-Cell CLLB-Cell Chronic Lymphocytic LeukemiaB-Cell Chronic Lymphogenous LeukemiaB-Cell Chronic Lymphoid LeukemiaB-Cell Lymphocytic LeukemiaB-Lymphocytic LeukemiaBiologicalBloodBlood CellsBlood FractioningBlood Precursor CellBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesCancersCardiovascular DiseasesCell BodyCell Growth in NumberCell LineageCell MultiplicationCell ProliferationCellsCellular ProliferationChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome abnormalityChromosomesChronic B-Lymphocytic LeukemiaChronic DiseaseChronic IllnessChronic Lymphatic LeukemiaChronic Lymphoblastic LeukemiaChronic Lymphocytic LeukemiaChronic Lymphogenous LeukemiaClonal ExpansionClonal Hematopoietic Stem CellClonal expansion of hematopoietic cellsClonal expansion of hematopoietic stem cellsClonal hematopoietic expansionCollectionComputing MethodologiesCytogenetic AberrationsCytogenetic AbnormalitiesDNADNA mutationDataDeoxyribonucleic AcidDevelopmentDiseaseDisease OutcomeDisorderEnvironmental FactorEnvironmental Risk FactorEpidemiologyExpression SignatureFemale HealthGene ExpressionGene Expression ProfileGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenomeGenomic approachGenomicsHealthHematologyHematopoietic Progenitor CellsHematopoietic stem cellsHost FactorHost Factor ProteinHumanImmuneImmunesIndividualInfectionInflammationInflammatoryIntegration Host FactorsInterventionKidney DiseasesKnowledgeLeadLearningLoss of HeterozygosityLung DiseasesLymphoidMalignant NeoplasmsMalignant TumorMapsMeasuresMediatingMethodsModelingModern ManMolecularMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMosaicismMulti-Ethnic Study of AtherosclerosisMutateMutationMyelogenousMyeloidNHLBINational Heart, Lung, and Blood InstituteNational Institutes of HealthNephropathyOlder PopulationOrganismPathway interactionsPatternPb elementPeripheral Blood CellPhenotypePneumoniaPoint MutationPopulationPredictive FactorPredisposing FactorProcessPulmonary DiseasesPulmonary DisorderRNA SeqRNA sequencingRNAseqRenal DiseaseResearch ActivityRiskRisk FactorsSamplingSiteSomatic MutationSurvey InstrumentSurveysTOPMedTimeTissuesTrans-Omics for Precision MedicineUnited States National Institutes of HealthWomen's HealthWorkage related pathwaysagesaging associated diseaseaging associated disordersaging associated mechanismaging mechanismaging pathwayaging related diseaseaging related disordersaging related mechanismaging related pathwaysbiobankbiologicbiological mechanism of agebiological pathways of agebiorepositoryblood cell progenitorblood fractionationblood progenitorblood stem cellblood-forming stem cellcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcardiovascular healthcell typechromosomal defectchromosome defectchronic disorderchronic lymphoid leukemiaclinical phenotypeclonal expansions in the bloodclonal hematopoiesisclone hematopoietic stem cellclones in hematopoietic cellscohortcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddevelopmentaldifferential expressiondifferentially expresseddisease associated with agingdisease of agingdisease of the lungdisease riskdisorder of agingdisorder of the lungdisorder riskdisorders associated with agingdisorders related to agingentire genomeenvironmental riskepidemiologicepidemiologicalfull genomegene expression patterngene expression signaturegenome mutationgenomic datagenomic datasetgenomic effortgenomic strategyhealthy aginghealthy human agingheavy metal Pbheavy metal leadhematopoietic cell cloneshematopoietic progenitorhematopoietic stem cell clonalityhematopoietic stem progenitor cellhemopoietic progenitorhemopoietic stem cellhigh riskimprovedindividualized preventioninsightkidney disorderlife spanlifespanliving systemlung disordermalignancymechanism regulating agingmechanisms involved in agingmolecular modelingmortalitymosaicmosaic diseasesmosaic disordersmultidisciplinaryneoplasm/cancernovelolder groupsolder individualsolder personpathwaypathway involved in agingpersonalized preventionphenomepopulation healthprecision preventionprogenitor cell differentiationprogenitor differentiationprogramsprospectiverenal disorderscRNA sequencingscRNA-seqscreeningscreeningssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsomatic variantstatisticsstem and progenitor differentiationstem cell differentiationsuccesstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic agent developmenttherapeutic developmenttranscriptional differencestranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingwhole genome
Description preview
Project Summary
With age, dividing cells acquire DNA mutations. A small number of these somatic mutations confer a selective
advantage leading to a clonal proliferation of cells harboring the somatic mutation. In blood, this process is
termed ‘clonal hematopoiesis’. These mutations include both point mutations in cancer driver genes (eg. clonal…
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