grant
Establishing the development basis for the morphological and functional asymmetry of the human chorion
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Aug 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20262nd trimesterAnatomic SitesAnatomic structuresAnatomyArteriesAssayBioassayBiological AssayBloodBlood Reticuloendothelial SystemBlood flowCell BodyCell Communication and SignalingCell SignalingCellsCells Placenta-TissueChorionChorionic SacChorionic villiConditioned Culture MediaConditioned MediumDataDeciduaDecidua BasalisDecidua GraviditasDefectDevelopmentDiseaseDisorderDissectionDysfunctionEPH GestosisEmbryoEmbryonicEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpitheliumFecundabilityFecundityFertilityFetal Growth RestrictionFetal Growth RetardationFetal MembranesFunctional disorderGene TranscriptionGenerationsGenetic TranscriptionGestationGoalsHumanIUGRImmuneImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsInflammatoryIntracellular Communication and SignalingIntrauterine Growth RetardationInvadedInvestigationLearningLigandsLocationMapsMaternal placentaMidtrimesterModelingModern ManMolecularMorphologyNormal PlacentomaObesityOrganoidsPathway interactionsPhysiopathologyPlacentaPlacenta Embryonic TissuePlacental VilliPlacentomePolycystic Ovarian DiseasePolycystic Ovarian SyndromePolycystic Ovary SyndromePopulationPre-EclampsiaPreeclampsiaPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy ToxemiasPremature LaborPremature Obstetric LaborPreterm LaborProcessProgenitor CellsPropertyProteinuria-Edema-Hypertension GestosisPublishingRNA ExpressionRNA SeqRNA sequencingRNAseqReceptor ProteinRepressionRiskSclerocystic Ovarian DegenerationSclerocystic Ovary SyndromeSecond Pregnancy TrimesterSecond TrimesterSignal TransductionSignal Transduction SystemsSignalingSiteSourceStratified EpitheliumSurfaceSurvey InstrumentSurveysSyncytiotrophoblastTestingTranscriptionUteroplacental CirculationUterusVillousVillusWorkadipositybiological signal transductioncandidate identificationcomplications during pregnancycorpulencecytotrophoblastdevelopmentalearly in pregnancyearly pregnanciesearly pregnancyearly pregnancy lossearly stage of pregnancyendometriosisepigeneticallyexperimentexperimental researchexperimental studyexperimentsfetalfetus membraneglobal gene expressionglobal transcription profileimpaired fetal growthimplantationinsightinterestintra-uterine growth restrictionintra-uterine growth retardationintrauterine growth restrictionmigrationnovelpathophysiologypathwayplacental membranepolycystic ovarypolycystic ovary diseasepolycystic ovary disorderpre-eclampticpregnancy toxemia/hypertensionpregnancy-related complicationsprenatal growth disorderprogenitorprogenitor cell differentiationprogenitor cell fateprogenitor differentiationprogenitor fateprogramsprotein profilingreceptorscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem and progenitor cell fatestem and progenitor differentiationstem cell differentiationstem cell fatestem cellssuccesstheoriestranscriptometranscriptome sequencingtranscriptomic sequencingtrophoblasttrophoblast progenitortrophoblast progenitor celltrophoblast stem cellwomb
Description preview
Abstract
Project 3 aims to understand the origins of asymmetry in the human chorion and whether defects in the
component processes arise early in pregnancy. The goal is to test the hypothesis that the smooth chorion (SC
or chorion laeve)—the outer surface of the fetal membranes—arises via a cytotrophoblast (CTB) developmental
program distinct from…
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