grant
Erythroblastic Island Macrophages in SCD Disordered Erythropoiesis.
Organization NEW YORK BLOOD CENTERLocation NEW YORK, UNITED STATESPosted 20 Jul 2020Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025AgonistAnemiaAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoptoticAutoantibodiesBabesia infectionBabesia parasite infectionBabesiosisBlood DiseasesBlood granulocytic cellBody TissuesCCL8CCL8 geneCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsChemicalsChemotactic CytokinesChloroheminCo-cultureCocultivationCocultureCoculture TechniquesCollaborationsCompensationDNA TherapyDataDevelopmentDiseaseDisorderDown-RegulationEPO-REnvironmentErythroblastsErythroid CellsErythroid Precursor CellsErythroid Progenitor CellsErythroid Stem CellsErythropoiesisErythropoietic Progenitor CellsErythropoietic Stem CellsErythropoietin ReceptorFerriheme ChlorideFerriprotoporphyrin IX ChlorideFerroprotoporphyrinGene ExpressionGene Transfer ClinicalGenetic InterventionGranular LeukocytesGranulocytic cellGrowth AgentsGrowth FactorGrowth SubstancesHC14HSC transplantationHb SS diseaseHbSS diseaseHematologic DiseasesHematological DiseaseHematological DisorderHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationHemeHeminHemoglobin S DiseaseHemoglobin sickle cell diseaseHemoglobin sickle cell disorderHemolysisHemopexinHepaticHomolog of Drosophila TOLLHomologous Chemotactic CytokinesHumanIGF1IGF1 geneIGFIImmunoglobulin Enhancer-Binding ProteinImpairmentIn VitroInflammationInflammation MediatorsInflammatoryIntercrinesIntracellular Communication and SignalingIslandKO miceKnock-out MiceKnockout MiceLiverMCP-2MCP2MacrophageMediatingMetabolicMiceMice MammalsModern ManMotilityMurineMusMφNF-kBNF-kappa BNF-kappaBNFKBNecrosisNecroticNormoblastsNuclear Factor kappa BNuclear Transcription Factor NF-kBNucleated ErythrocytesNucleated red blood cellNucleated red cellNucleusNull MousePhagocytesPhagocytic CellPhagocytosisPhenotypePhosphorylationPiroplasmosisProductionProtein PhosphorylationProteins Growth FactorsProtohemeProtoheminReceptor ProteinReceptor SignalingRoleSCYA10SCYA8SIS cytokinesSickle Cell AnemiaSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStressSupplementationT-CellsT-LymphocyteTLR4TLR4 geneTestingTherapeuticTissuesToll HomologueTranscription Factor NF-kBTransfusionTransmissionTransplantationUpregulationamebocyteautoimmune antibodyautoreactive antibodybiological signal transductionblood disorderblood stem cell transplantationchemoattractant cytokinechemokinecytokinedevelopmentalerythroid developmenterythroid progenitorerythroid-committed progenitorserythrolysisferrohemegene repair therapygene therapygene-based therapygenetic therapygenomic therapygranulocytehematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic progenitor cell transplantationhepatic body systemhepatic organ systemimprovedin vivoinfected with Babesiainflammatory mediatorinhibitorinsightinterestkappa B Enhancer Binding Proteinknock-downknockdownknockout genemigrationmouse modelmurine modelnovelnuclear factor kappa betanucleated RBCsprogenitor cell proliferationprogenitor proliferationreceptorrecruitself reactive antibodysickle cell diseasesickle cell disordersickle diseasesicklemiasocial rolestem and progenitor cell proliferationstem cell proliferationthymus derived lymphocytetoll-like receptor 4transmission processtransplanttransplant therapytransplant treatmenttransplantation therapytransplantation treatment
Description preview
Erythroblastic island macrophages (EBI M) are niche cells for erythropoiesis. Alterations in EBI M contribute
to the disordered erythropoiesis in various hematological diseases. We have documented that EBI M are
characterized by the expression of erythropoietin receptor (EPOR) and that EPO/EPOR signaling in EBI M
promotes EBI formation and…
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