grant
EpiGNOME: Epigenetic Graphical Networks Of Methylation Effectors for COPD Progression
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Jan 2025Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2026AddressAffectAgingAlgorithmsBig DataBigDataBiopsyBloodBlood Reticuloendothelial SystemBlood leukocyteBody TissuesCAT scanCOPDCT X RayCT XrayCT imagingCT scanCause of DeathChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseClinicalClinical DataClinical SciencesCohort StudiesComplexComputational BiologyComputed TomographyComputer ModelsComputerized ModelsDNADNA MethylationDNA analysisDataData SetDeoxyribonucleic AcidDetectionDevelopmentDiagnosisDifferences between sexesDiffers between sexesDiseaseDisease ManagementDisease OutcomeDisease ProgressionDisorderDisorder ManagementElementsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFoundationsFutureGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGeneticGenetic DiversityGenetic VariationGenomicsGraphHealth Care CostsHealth CostsHigh-dimensional ModelingImageIndividualInvestigationKnowledgeLeukocytesLeukocytes Reticuloendothelial SystemLinkLogicLungLung DiseasesLung ParenchymaLung Respiratory SystemLung TissueMachine LearningMarrow leukocyteMeasuresMethodologyMethodsMethylationModelingModernizationMolecularNHLBINational Heart, Lung, and Blood InstitutePathogenesisPathway interactionsPatientsPhenotypePopulationPrecision Medicine InitiativePrognosisPulmonary DiseasesPulmonary DisorderResearchResearch ResourcesResourcesRoleSamplingSex DifferencesSexual differencesShapesSmokingStable DiseaseStructure of parenchyma of lungSyndromeSystems BiologyTOPMedTestingTherapeuticTherapeutic InterventionTissuesTomodensitometryTrans-Omics for Precision MedicineTranscript Expression AnalysesTranscript Expression AnalysisTranslational ResearchTranslational ScienceWhite Blood CellsWhite CellWorkX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyalgorithm developmentanalytical methodanalyze DNAanalyze gene expressionanalyzing longitudinalcatscanchronic obstructive pulmonary disordercohortcohort research studycohort surveycomputational frameworkcomputational modelingcomputational modelscomputed axial tomographycomputer based modelscomputer based predictioncomputer biologycomputer frameworkcomputer tomographycomputerized axial tomographycomputerized modelingcomputerized tomographycopingdeath riskdeep learningdeep learning methoddeep learning strategydesigndesigningdevelopmentaldisabilitydisease of the lungdisease preventiondisease subgroupsdisease subtypedisorder of the lungdisorder preventiondisorder subtypeepigenetic biomarkerepigenetic markerepigeneticallyepigenomeexpression subtypesgene expression analysisgene expression assaygenome scalegenome-widegenomewidegraph learninghigh dimensional datahigh dimensionalityimaginginnovateinnovationinnovativeinsightintervention therapylarge data setslarge datasetslearning algorithmlongitudinal analysislung disorderlung function declinemachine based learningmethylomemolecular imagingmolecular sub-typesmolecular subsetsmolecular subtypesmolecule imagingmortality riskmulti-modal datamulti-modal datasetsmulti-modalitymulti-scale datamultidimensional datamultidimensional datasetsmultidimensional modelingmultidisciplinarymultimodal datamultimodal datasetsmultimodalitymultiomicsmultiple omicsmultiscale datanon-contrast CTnoncontrast CTnoncontrast computed tomographynovelpanomicspathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespre-clinicalpreclinicalpredictive modelingprognosticprogramspulmonarypulmonary function declineresponsesex based differencessex-dependent differencessex-related differencessex-specific differencessocial rolestatisticssuccesstherapeutic targettooltranscriptional profilingtranslation researchtranslational investigationwhite blood cellwhite blood corpuscle
Description preview
EpiGNOME: Epigenetic Graphical Networks Of Methylation Effectors for COPD Progression
ABSTRACT
Modern clinical and translational sciences rely on big data to identify drivers of disease progression and develop
predictors of disease outcomes. Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death
and likely represents several…
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