grant
Epigenomics of Mutant p53
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20253rd generation sequencingATAC sequencingATAC-seqATACseqAccelerationAnti-OncogenesAntioncogene Protein p53AntioncogenesArchitectureAssayAssay for Transposase-Accessible Chromatin using sequencingAutoregulationBACH1BACH1 geneBasal Transcription FactorBasal transcription factor genesBioassayBioinformaticsBiologicalBiological AssayBiologyBody TissuesCUT&RUNCancer BiologyCancer ModelCancer Suppressor GenesCancerModelCancersCell BodyCellsCellular Tumor Antigen P53ChIP SequencingChIP-seqChIPseqChromatinChromatin StructureCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseComputer AnalysisConsultationsCopy Number PolymorphismDNADNA BindingDNA Binding InteractionDNA boundDNA mutationDataData AnalysesData AnalysisData SetDedicationsDeoxyribonucleic AcidDiseaseDisorderEmerogenesEngineering / ArchitectureEnsureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventExpression SignatureFertilizationFloorFosteringGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGenomicsGroup MeetingsHeterogeneityHistonesHomeostasisHumanImpairmentIn VitroIndividualInstitutionInvadedInvestigationInvestigatorsLeadMaintenanceMalignant NeoplasmsMalignant TumorMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorModern ManMutationNGS MethodNGS systemNeoplasm MetastasisNormal TissueNormal tissue morphologyOnco-Suppressor GenesOncogenes-Tumor SuppressorsOncogenesisOncogenicOncoprotein p53OutcomeP53PatternPb elementPhosphoprotein P53Phosphoprotein pp53Physiological HomeostasisPopulationPostdocPostdoctoral FellowPreparationPropertyProtein TP53Quality ControlRNA ExpressionRNA SeqRNA sequencingRNAseqRecessive OncogenesRegulatory ElementReportingResearch AssociateResearch DesignResearch PersonnelResearch ResourcesResearchersResourcesRoleSamplingSecondary NeoplasmSecondary TumorService provisionServicesStandardizationStudy TypeSystemTCGATP53TP53 geneTRP53TechniquesTechnologyTestingThe Cancer Genome AtlasThird Generation SequencingTissuesTrainingTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTumor BiologyTumor Protein p53Tumor Protein p53 GeneTumor Suppressing GenesTumor Suppressor GenesValidationVariantVariationVisualizationVisualization softwareWorkassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingassociate facultyassociate professorbio-informatics pipelinebio-informatics toolbioinformatics pipelinebioinformatics toolbiologiccancer metastasischromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcomplex datacomputational analysescomputational analysiscomputational pipelinescomputational resourcescomputer analysescomputing resourcesconsultationcopy number variantcopy number variationdata hubdata integrationdata interpretationdata toolsdata visualizationdesigndesigningepigeneticallyepigenomeepigenomicsexperiencefertilizationsgain of functiongene expression patterngene expression signaturegenome mutationgenome scalegenome-widegenomewideglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadhistone modificationimprovedin vivoinnovateinnovationinnovativeinsightinstrumentationinternet based platforminternet platformlarge scale datalarge scale data setslarge scale datasetslong read seqlong-read sequencinglong-read transcript sequencingmalignancymedical collegemedical schoolsmembermid-career facultymidcareer facultymutantneoplasm/cancernext gen sequencingnext generation sequencingnextgen sequencingnoveloncosuppressor genep53 Antigenp53 Genesp53 Tumor Suppressorpharmacologicpost-docpost-doctoralpost-doctoral traineepreparationsprofessorprogramsprotein p53research associatesresponsescATAC sequencingscATAC-seqschool of medicinesharing hubsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell sequencing assay for transposase accessible chromatinsingle cell technologysingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstudent trainingstudy designsynergismtech developmenttechnology developmenttranscription factortranscriptional profiletranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstumortumor cell metastasistumorigenesisvalidationsvisualization toolweb based platformweb based systemweb enabled platformweb platform
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PROJECT SUMMARY
The primary objective of Core 1, “Epigenomics of mutant p53” is to provide state-of-the-art transcriptomic and
epigenomic experimental approaches, next generation sequencing (NGS) expertise, computational analysis and
bioinformatic tools for data visualization, and integration of large ‘omic datasets across all Projects of this…
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