grant
Epigenomic Pathways from Racism to Preterm Birth
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 14 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY202537 weeks completed gestation37 weeks gestationAddressAffectBehavioralBiologicalBirthBlackBlack raceBloodBlood Reticuloendothelial SystemBlood SampleBlood specimenBody TissuesCandidate Disease GeneCandidate GeneCaucasian FemalesCaucasian WomenClimateCognitive DiscriminationDNADNA MethylationDataDeoxyribonucleic AcidDiscriminationEWASEconomic IncomeEconomical IncomeEnsureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquityEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationExposure toFutureGene ExpressionGenesGenomic SegmentGeographic AreaGeographic LocationsGeographic RegionGeographical LocationGestationGoalsHealthHealth InequityHealth PolicyHigh Risk WomanHispanicHispanic FemalesHispanic WomenHomeImmigrantIncomeIndividualInequalities in HealthInequities in HealthInfantInterventionKnowledgeLong-term cohort studyLongitudinal StudiesLongitudinal cohort studyMapsMaternal HealthMeasuresMediatingMeteorological ClimateMethylationModelingMothersNational Institutes of HealthNon-HispanicNonhispanicNot Hispanic or LatinoNulliparasNulliparityNulliparousOutcomeOwnershipParticipantParturitionPathway interactionsPerinatalPerinatal MortalitiesPerinatal lethalityPerinatal mortality demographicsPeripartumPersonsPhenotypePolicy DevelopmentsPoliticsPregnancyPregnancy ComplicationsPregnant WomenPremature BirthPrematurely deliveringPreterm BirthPreventionRaceRacesRacial GroupResearchRiskRisk FactorsServicesSiteSocietiesStrategic PlanningStressStructural RacismSubgroupTissuesUnited StatesUnited States National Institutes of HealthWhite FemalesWhite WomenWomanWomen's cohortadverse birth outcomesadverse consequenceadverse outcomeat-risk femalesat-risk womenbiologicblack femaleblack womenclimaticcohortcohort in womencohort on womencomparator groupcomparison groupcomplications during pregnancydisparities in racedisparity due to racedisparity in ethnicearly in pregnancyearly pregnanciesearly pregnancyearly stage of pregnancyepigeneticallyepigenomeepigenome wide association analysisepigenome-wide association studiesepigenomicsethnic based disparityethnic disadvantageethnic disparityethnic inequalityethnic inequityethnic subgroupethnicity disparityethnicity groupexpectant motherexpectant womenexpecting motherexpecting womenexperienceexperienced discriminationexposed in uterofemale cohortfemale outcomesfemales at high riskfetal exposuregenome segmentgenomic regiongeographic sitehealth care policyhealth inequalitieshigh risk femaleshomesimprovedin utero exposureincomesindividuals who are pregnantinequality due to raceinequity due to raceintra-uterine environmental exposureintrauterine environmental exposurelong-term sequelaelong-term studylongitudinal outcome studiesmaternal stressmethylation biomarkermethylation markermethylomemolecular biomarkermolecular markermultidisciplinarymultiomicsmultiple omicsnoveloutcomes among femalesoutcomes among womenoutcomes in femalesoutcomes in womenpanomicspathwaypeople who are pregnantperceived discriminationperception of discriminationperinatal deathsperinatal healthperinatal morbiditypopulation healthpregnancy-related complicationspregnant femalespregnant motherspregnant peoplepregnant populationspremature childbirthpremature deliveryprenatalprenatal exposureprenatally exposedpreterm deliveryprospectiverace based disparityrace based inequalityrace based inequityrace disparityrace related disparityrace related inequalityrace related inequityracialracial backgroundracial disparityracial inequalityracial inequityracial originracial populationracial subgroupracially unequalracismresidential segregationself-reported discriminationsocial determinantssociodeterminantstressed mothersstressorthose who are pregnantunbornwomen at high riskwomen of colorwomen who are pregnantwomen's outcomes
Description preview
Preterm birth (PTB) is a leading cause of perinatal morbidity and mortality, with long-term sequelae for both
mother and infant. Despite many known risk factors for PTB, prevention and treatment options are limited.
Non-Hispanic (NH) Black women are 2-3 times more likely to experience PTB compared to NH White women,
and some subgroups of Hispanic…
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