grant
Epigenetics of Aging and Age-Associated Diseases
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAgeAgingAreaAutoregulationBody TissuesBrainBrain Nervous SystemCell AgingCell BodyCell Communication and SignalingCell NucleusCell SenescenceCell SignalingCell modelCellsCellular AgingCellular SenescenceCellular modelChemotactic CytokinesChromatinCoinCryo-electron MicroscopyCryoelectron MicroscopyCytoplasmDNADedicationsDeoxyribonucleic AcidDevelopmentDiabetes MellitusDiseaseDisorderElectron CryomicroscopyEncephalonEnhancersEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFatty LiverFosteringFoundationsFundingFutureGene ExpressionGene TranscriptionGenetic TranscriptionHepatic CancerHepatic FailureHomeostasisHomologous Chemotactic CytokinesImmuneImmunesImmunoglobulin Enhancer-Binding ProteinInflammatoryIntercrinesIntracellular Communication and SignalingLength of LifeLiverLiver DysfunctionLiver FailureLiver SteatosisLongevityMacromolecular StructureMalignant neoplasm of liverMetabolicMetabolic DiseasesMetabolic DisorderMetabolic dysfunctionMiceMice MammalsMolecularMolecular StructureMolecular TargetMurineMusNF-kBNF-kappa BNF-kappaBNFKBNatureNuclearNuclear Factor kappa BNuclear Transcription Factor NF-kBNucleusPaperPathway interactionsPhasePhenotypePhysiological HomeostasisProcessProductivityProgress ReportsProliferatingPublishingRNA ExpressionRegulationReplicative SenescenceRisk FactorsRoleSIS cytokinesSignal TransductionSignal Transduction SystemsSignalingSingle Crystal DiffractionStimulator of Interferon GenesStressStructureTalentsTestingThesaurismosisTissuesTranscriptionTranscription Factor NF-kBX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentagesaging associatedaging induced epigenetic changeaging relatedaging-associated epigenetic changeaging-related epigenetic changebiological signal transductioncGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGchemoattractant cytokinechemokinechromatin remodelingcryo-EMcryoEMcryogenic electron microscopycyclic GMP-AMP synthase/STINGcytokinedevelop therapydevelopmentaldiabetesepigenetic agingepigenetic mechanisms in agingepigenetic modifications in agingepigenetic regulation of agingepigeneticallyepigenomefallsfatty liver diseasehealthspan extending interventionhealthspan extending therapieshealthspan interventionhealthspan promoting interventionhealthspan promoting therapieshealthspan therapieshealthy aging interventionhepatic body systemhepatic organ systemhepatic steatosishepatosteatosishistone modificationimprovedin vivoinhibitorinnovateinnovationinnovativeinsightintervention developmentintervention to promote healthy aginginterventions to improve healthspankappa B Enhancer Binding Proteinliver cancerliver malignancymalignant liver tumormetabolism disordermouse modelmurine modelnovelnuclear factor kappa betapathwaypromoterpromotorreplicative agingresponserestraintsenescencesenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescentsenescent associated secretomesenescent associated secretory phenotypesenescent cellsmall moleculesocial roletherapy developmentthree dimensionaltooltreatment development
Description preview
In the previous active cycle of this PPG “Epigenetics of aging and age-associated diseases” (2018-2023), we
proposed to focus on two main aspects of “epigenetics of aging”, namely chromostasis and regulation of the
senescence-associated secretory phenotype (SASP) of senescent cells.
This PPG coined the term “chromostasis” to conceptualize the…
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