grant
Epigenetic studies in rhabdomyosarcoma
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AlgorithmsAlveolarAlveolar RhabdomyosarcomaAntioncogene Protein p53ArchitectureBeadChipBiologicalBloodBlood Reticuloendothelial SystemBody RegionsBody TissuesBone SarcomaCancersCategoriesCausalityCell BodyCellsCellular Tumor Antigen P53ChildhoodChildhood CancersChildhood RhabdomyosarcomaChildren's Oncology GroupChromatinClassificationClinicalCold-Insoluble GlobulinsCollaborationsDICER GeneDICER1DICER1 geneDNA MethylationDNA methylation profilingDNA mutationDataDevelopmentDiagnosticDifferential Gene ExpressionEmbryonal RhabdomyosarcomaEngineeringEngineering / ArchitectureEosinophilic GranulomaEosinophilic Xanthomatous GranulomaEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyEventFKHRFN1FOXO1FOXO1AFOXO1A geneFamilyFibronectin 1FibronectinsForkhead Box O1AForkhead in RhabdomyosarcomaFreezingGene FusionGene TranscriptionGeneralized HistiocytosisGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomic DNAGerm LinesGoalsHERNAHUP1HUP2Helicase with RNase MotifHelicase-MOIHistiocytosis XHistologyHypermethylationInflammatory FibrosarcomaInflammatory Myofibroblastic NeoplasmInflammatory Myofibroblastic TumorInflammatory PseudotumorK12H4.8-LikeKIAA0928LETS ProteinsLangerhans-Cell GranulomatosisLangerhans-Cell HistiocytosisLarge External Transformation-Sensitive ProteinLetterer-Siwe DiseaseMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant Soft Tissue NeoplasmMalignant TumorMalignant childhood cancerMethodsMethyl-SeqMethylSeqMethylationMethylation sequencingMolecularMutationOncogenicOncoprotein p53Opsonic GlycoproteinOpsonic alpha(2)SB GlycoproteinOsseous SarcomaOsteogenic SarcomaOsteosarcomaOther GeneticsOutcomeP53PAX3PAX3 genePAX7PAX7 genePaired Box Gene 3Paired Box Gene 7Paired Box Homeotic Gene 7Paired Domain Gene 7Paired Domain Gene HuP2Pathway interactionsPatternPediatric Oncology GroupPediatric RhabdomyosarcomaPhosphoprotein P53Phosphoprotein pp53Point MutationPrincipal Component AnalysesPrincipal Component AnalysisPromoter RegionsPromotor RegionsProtein TP53PublishingRNA ExpressionRas Signaling PathwayRecurrenceRecurrentRhabdomyosarcomaSamplingSarcomaSkeletal MuscleSkeletal SarcomaSpindle Cell NeoplasmSpindle Cell TumorSystematicsTP53TP53 geneTRP53Tissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesTranscriptionTumor CellTumor Protein p53Tumor Protein p53 GeneTumor-DerivedVoluntary MuscleWS1alpha 2-Surface Binding Glycoproteinbead chipbiologiccancer in a childcancer in childrencausationchild with cancerchildhood malignancycohortdensitydevelopmentaldisease causationepigeneticallyexome sequencingexome-seqfusion detectionfusion gene detectionfusion screeninggDNAgenetic promoter elementgenetic promoter sequencegenome mutationgenome scalegenome wide analysisgenome wide methylationgenome wide studiesgenome-widegenome-wide analysisgenome-wide identificationgenomewidegenomewide methylationglobal methylationmalignancymalignant soft tissue tumormethylation patternmouse modelmurine modelmutantneoplasm/cancerneoplastic cellosteochondrosarcomaosteoid sarcomap53 Antigenp53 Genesp53 Tumor Suppressorpathwaypediatricpediatric cancerpediatric malignancypromoterpromoter sequencepromotorprotein p53soft tissuetumor
Description preview
In previous studies, we established a cohort of frozen samples derived from 223 RMS tumors to investigate the biological and clinical signi?cance of global DNA methylation patterns in pediatric RMS. Unsupervised analysis of the genome-wide DNA methylation patterns in this large cohort con?rmed that these RMS cases can be divided into two major…
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