grant
Epigenetic Silencing of Inhibitor of Differentiation 4 (ID4) Promotes Stem Cell and Castration Resistant Phenotype in Prostate Cancer
Organization CLARK ATLANTA UNIVERSITYLocation ATLANTA, UNITED STATESPosted 1 Jun 1997Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AKTAddressAkt proteinAndrogen ReceptorAntioncogene Protein p53ApoptoticAthymic MiceAthymic Nude MouseAttenuatedBiologyCD44CD44 geneCancer GenesCancer-Promoting GeneCancersCastrationCell BodyCell Communication and SignalingCell SignalingCellsCellular Tumor Antigen P53ChaperoneChemotherapy and RadiationChemotherapy and/or radiationClinicalCombined Modality TherapyComplexDNA MethylationDU-145DU145DevelopmentDifferentiation InhibitorENX-1EZH1EZH2EZH2 geneEnhancer of Zeste 2 Polycomb Repressive Complex 2 SubunitEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpithelial CellsEpithelium of Human Prostate GlandExhibitsFK506 binding protein 5FK506 binding protein 59FK506-binding protein 4FKBP4FKBP51FKBP52FKBP54FKBP59Gene TranscriptionGeneralized GrowthGenetic TranscriptionGoalsGrowthHSP 56HSP56HTH DNA Binding DomainHTH MotifsHelix-Turn-Helix MotifsHomeobox Protein NKX-3.1Homeobox Protein NKX3AIndividualInterventionIntracellular Communication and SignalingKMT6KMT6AKO miceKnock-out MiceKnockout MiceLNCaPLigandsMDU3MMAC1MMAC1 proteinMalignant CellMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMiceMice MammalsMolecularMolecular ChaperonesMorphogenesisMultimodal TherapyMultimodal TreatmentMurineMusMutated in Multiple Advanced Cancers 1NK Homeobox Family 3 Subunit A HomologNK3 Transcription Factor Homolog ANK3 Transcription Factor Related ProteinNKX3-1 geneNKX3.1NKX3ANatural regenerationNkx-3.1 proteinNude MiceNull MouseOncogenesOncogenicOncoprotein p53P53PC-3PC-3 cell linePC3PC3 cell linePHTS genePHTS proteinPTENPTEN genePTEN proteinPTEN1Pathway interactionsPgp1PhenotypePhosphatase and Tensin HomologPhosphatase and Tensin Homolog Deleted on Chromosome 10Phosphoprotein P53Phosphoprotein pp53PreventionProgenitor CellsPropertyProstateProstate CAProstate CancerProstate GlandProstate malignancyProstatic EpitheliumProstatic GlandProtein Kinase BProtein TP53Proto-Oncogene Proteins c-aktRAC-PK proteinRNA ExpressionRegenerationRegulationResistanceRoleSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedStem Cell likeSteroid ReceptorsSurgical CastrationTP53TP53 geneTRP53TherapeuticTissue GrowthTranscriptionTransforming GenesTumor PromotersTumor PromotionTumor Protein p53Tumor Protein p53 GeneTumor Suppressor ProteinsTumorigenicityUniversitiesUpregulationadvanced prostate canceralpha helixandrogen dependentandrogen independent prostate cancerandrogen indifferent prostate cancerandrogen insensitive prostate cancerandrogen resistance in prostate cancerandrogen resistant prostate cancerandrogen responsiveandrogen sensitiveanti-cancer researchattenuateattenuatesbiological signal transductionc-akt proteincancer biomarkerscancer cellcancer cell stemnesscancer markerscancer progenitorcancer progenitor cellscancer progressioncancer researchcancer stem cellcancer stem cell likecancer stem like cellcancer stemnesscancer survivalcastration resistant CaPcastration resistant PCacastration resistant prostate cancerchemo/radiation therapychemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationschemotherapy and radiotherapycombatcombination therapycombinatorialcombined modality treatmentcombined treatmentconstitutive expressionconstitutive gene expressiondevelopmentaleffective therapyeffective treatmentepigenetic gene silencingepigenetic silencingepigeneticallyheat shock-binding immunophilinheat-shock protein 56helix loop helixhelix turn helixhistone methylationhormone refractory prostate cancerinducible expressioninducible gene expressionmalignancymalignant progenitormalignant stem cellmorphogenetic processmulti-modal therapymulti-modal treatmentmutated in multiple advanced cancers 1 proteinneoplasm progressionneoplasm/cancerneoplastic progressionnoveloncogenic progenitoroncogenic stem cellsontogenyp53 Antigenp53 Genesp53 Tumor Suppressorp59 heat shock-binding immunophilinpathwayphosphatase and tensin homologue on chromosome tenpreventpreventingprogenitor capacityprogenitor cell likeprogenitor cell markersprogenitor cell poolprogenitor cell populationprogenitor like cancer cellprogenitor markersprogenitor poolprogenitor populationprogenitor stem cell markersprogenitor-likeprogramsprostate cancer cell lineprostate cancer progressionprostate cancer resistant to androgenprotein p53proto-oncogene protein RACproto-oncogene protein aktrac protein kinaseradiation or chemotherapyreceptor expressionregenerateregenerativerelated to A and C-proteinresistantsmall moleculesocial rolestem and progenitor cell populationstem cell biomarkersstem cell characteristicsstem cell markersstem cell poolstem cell populationstem cellsstem like cancer cellstem-likestemnessstemness in cancertacrolimus binding protein 4tacrolimus binding protein 5therapeutically effectivetumortumor initiationtumor progressiontumor suppressorα-helix
Description preview
PROJECT SUMMARY/ABSTRACT
PROJECT 2
Androgen receptor (AR), is essential for normal prostate development where it acts mainly as a tumor
suppressor. In prostate cancer (PCa), AR transitions to a potent oncogene by supporting the survival of cancer
cells. ID4, a helix loop helix (HLH) transcriptional regulator, is tumor suppressor that is…
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