grant
Epigenetic Regulation of Hypothalamic Energy Homeostasis
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 18 Mar 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026Arcuate NucleusAreaAutoregulationBiologyBody TissuesBody WeightBody Weight decreasedBrainBrain Nervous SystemCNS Nervous SystemCaloric RestrictionCell BodyCell Communication and SignalingCell SignalingCellsCentral Nervous SystemChemicalsCollaborationsCuesDataEC 2.1.1ESETEatingEncephalonEndocrine Gland SecretionEnergy ExpenditureEnergy MetabolismEnzyme GeneEnzyme TestsEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExpression SignatureFastingFeeding behaviorsFood IntakeGLP-1GLP-1 RAGLP-1 agonistGLP-1 analogGLP-1 receptor agonistGene Expression ProfileGene PoolGene TranscriptionGenesGenetic TranscriptionGenomeGliaGlial CellsGlp-1Glucagon like peptide 1 agonistGlucagon like peptide-1 receptor agonistsGlucagon-like peptide-1 analogGlutamatesHealthHistone H3HistonesHistoryHomeostasisHormonalHormonesHumanHungerHypothalamic structureHypothalamusInfundibular NucleusIngestive BehaviorIntracellular Communication and SignalingJointsKG1TKIAA0067Kolliker's reticulumL-GlutamateL-LysineLeannessLeptinLysineMaintenanceMapsMediatingMemoryMetabolicMethodsMethylationMethyltransferaseMiceMice MammalsModern ManModificationMolecularMurineMusNerve CellsNerve UnitNeural CellNeuranatomiesNeuranatomyNeuraxisNeuroanatomiesNeuroanatomyNeurocyteNeurogliaNeuroglial CellsNeuronsNon-neuronal cellNonneuronal cellNutrientNutritionalOb Gene ProductOb ProteinObese Gene ProductObese MiceObese ProteinObesityPhysiological HomeostasisPopulationProcessRNA ExpressionRecording of previous eventsRegulationResolutionRiskRodentRodentiaRodents MammalsRoleSETDB1SETDB1 geneSignal TransductionSignal Transduction SystemsSignalingStructure of nucleus infundibularis hypothalamiTarget PopulationsTestingThinnessTissuesTranscriptionWeightWeight GainWeight IncreaseWeight LossWeight ReductionWeight maintenance regimenadipositybiological signal transductionbody weight gainbody weight increasebody weight losscalorie restrictioncell typechromatin modificationco-morbidco-morbiditycomorbiditycorpulencedesigndesigningdiet-associated obesitydiet-induced obesitydiet-related obesityenergy balanceepigenetic biomarkerepigenetic markerepigenetic regulationepigeneticallyepigenomeexperiencefastedfastsfeedingfeeding-related behaviorsgene expression patterngene expression signaturegenetic approachgenetic strategyghrelinglobal gene expressionglobal transcription profileglucagon-like peptide 1glutamatergichistone H3 methyltransferasehistone demethylasehistone methylasehistone methylationhistone methyltransferasehistorieshypothalamicknock-downknockdownmembermethylasenerve cementneuronalnovelnutrient intake activitynutritiousob/ob mouseobesigenicobesity managementobesogenicpublic health relevanceresolutionsresponsesocial roletranscriptional profiletranscriptional signaturetranscriptometranscriptome profilingtranscriptomic profilingtranscriptomicstransmethylaseweight controlweight maintenanceweight managementweightswt gainwt-loss
Description preview
The regulation of body weight and food intake are under tight control by the hypothalamic circuits in the
central nervous system. Perturbations leading to weight gain or loss is usually countered by these circuits to
keep body weight within homeostatic limits, a process that is dysregulated in diet induced obesity. This
proposal presents…
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