grant
Epigenetic regulation of early B cell differentiation
NIHUS FederalResearch GrantFY20262019 novel corona virus2019 novel coronavirus2019-nCoVAOF2Ab responseAddressAdoptedAffectAnatomic SitesAnatomic structuresAnatomyAntibodiesAntibody FormationAntibody ProductionAntibody-Secreting CellsAntigensArchitectureAssayAutoimmune DiseasesB blood cellsB cellB cell differentiationB cellsB lymphocyte differentiationB-Cell ActivationB-Cell SubsetsB-CellsB-Lymphocyte SubsetsB-LymphocytesB-cellBacterial InfectionsBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBlood Plasma CellCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCOVID-19 virusCOVID19 virusCRE RecombinaseCell BodyCell Fate ControlCell Fate RegulationCell divisionCellsChickensChromatinCoV-2CoV2Communicable DiseasesCoupledDNADataDeoxyribonucleic AcidDiseaseDisorderDisparateDistalENX-1EZH1EZH2EZH2 geneEnabling FactorsEngineering / ArchitectureEnhancer of Zeste 2 Polycomb Repressive Complex 2 SubunitEnterobacteria phage P1 Cre recombinaseEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventExpression SignatureFicollFutureGallus domesticusGallus gallusGallus gallus domesticusGene ExpressionGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic TranscriptionGerminal CenterGlobulinsHeritabilityHeterogeneityHumoral ImmunitiesImmune Cell ActivationImmune mediated therapyImmune responseImmunityImmunochemical ImmunologicImmunoglobulin-Secreting CellsImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunotherapeutic agentImmunotherapyIn vivo analysisIndividualInfectious DiseasesInfectious DisorderInfluenza VirusIntermediary MetabolismKDM1AKDM1A geneKMT6KMT6AKineticsLSD1LipopolysaccharidesLiteratureLocationLysine-Specific Demethylase 1Lysine-Specific Demethylase 1AMediatingMemoryMemory B CellMemory B-LymphocyteMetabolic ProcessesMetabolismMiceMice MammalsModelingMolecularMurineMusParasitic infectionPathogenicityPathway interactionsPhasePlasma CellsPlasmacytesPlayProcessProliferatingRNA ExpressionRegulatory ElementReporterRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SeriesSerum GlobulinsSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2ShapesSourceStructureStructure of germinal center of lymph nodeSystemT-CellsT-LymphocyteT4 CellsT4 LymphocytesTestingTranscriptionTranscription Factor Proto-OncogeneTranscription ProcessTranscription factor genesTransgenic OrganismsVaccinesViral DiseasesVirus DiseasesWuhan coronavirusactivated B cellsadaptive immunityalpha-D-Glucopyranoside, beta-D-fructofuranosyl, homopolymerantibody biosynthesisantibody-based immunityautoimmune conditionautoimmune disorderautoimmunity diseasebacteria infectionbacterial diseasebacteriophage P1 recombinase Crebasebasesbiological adaptation to stressconditional knock-outconditional knockoutcongeniccoronavirus disease 2019 viruscoronavirus disease-19 virusdesigndesigningdifferential expressiondifferentially expressedepigenetic regulationepigeneticallyepigenomeepigenomicsgene expression patterngene expression signatureglobal gene expressionglobal transcription profilehCoV19host responseimmune activationimmune drugsimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunoglobulin biosynthesisimmunologic therapeuticsimmunoresponseimmunotherapeuticsimmunotherapy agentin vivoin vivo evaluationin vivo testinginfected with parasitesinfluenzavirusmouse modelmurine modelnCoV2parasite infectionpathwayplasmocyteprecursor cellprogramspromoterpromotorreaction; crisisresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestress responsestress; reactionthymus derived lymphocytetranscription factortranscriptional differencestranscriptional profiletranscriptional signaturetranscriptometranscriptomicstransgenicviral infectionvirus infectionvirus-induced disease
Description preview
Humoral immunity provides protection from pathogenic viral, bacterial, and parasitic infections and is mediated
by antibodies that are produced following the differentiation of B cells into antibody secreting cells (ASC). Both
T cell independent and dependent processes contribute to the formation of ASC, as well as memory B cells
(MBC); each of…
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