grant
Epigenetic modifications associated with intrauterine exposure to maternal type 2 diabetes.
Organization NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAHRRAdultAdult HumanAdult-Onset Diabetes MellitusAffectAgeAkimel O'odhamAmerican Indian PopulationAmerican Indian groupAmerican Indian individualAmerican Indian peopleAmerican IndiansAnimalsB9 endocrine pancreasBeadChipBeta CellBiologic ModelsBiologicalBiological ModelsBlood CellsBlood SampleBlood leukocyteBlood specimenBody TissuesCP11CY11CYP1A1CYP1A1 geneCardiovascular DiseasesCell Communication and SignalingCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SignalingCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationChildChild YouthChildren (0-21)ComplementComplement ProteinsCytosineD-GlucoseDNADNA MethylationData SetDeoxyribonucleic AcidDevelopmentDextroseDiabetes MellitusDiseaseDisorderEWASEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEndocrine PancreasEnhancer ElementsEnvironmentEnvironmental ExposureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationExposure toFutureGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGenesGenetic Enhancer ElementGenomicsGestationGlucoseGuanineHereditaryHumanHumulin RHypermethylationImpairmentIndigenous AmericanIndividualInflammationInheritedInsulinInsulin CellInsulin Secreting CellIntercistronic RegionIntergenic RegionsIntracellular Communication and SignalingIslands of LangerhansIslets of LangerhansKetosis-Resistant Diabetes MellitusLeukocytesLeukocytes Reticuloendothelial SystemLong-Term EffectsLongitudinal StudiesMapsMarrow leukocyteMaturity-Onset Diabetes MellitusMeasuresMetabolic DiseasesMetabolic DisorderMethylationMitoticModel SystemModern ManModificationMothersNIDDMNative American groupNative American individualNative American peopleNative American populationNative AmericansNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RObesityOnset of illnessP1-450P450-CP450DXP450D\XPancreatic IsletsPars endocrina pancreatisPathway interactionsPeripheral Blood CellPhosphatesPima IndianPopulationPregnancyRAS-Like Protein TC21RAS-Related Protein R-RAS2RNA SeqRNA sequencingRNAseqRRAS2RRAS2 geneRegular InsulinRelated RAS Viral (R-Ras) Oncogene Homolog 2ReportingRiskRoleSTC geneSTC proteinSTC1STC1 geneSamplingSiblingsSignal TransductionSignal Transduction SystemsSignalingSiteSlow-Onset Diabetes MellitusSomatic CellSourceStable Diabetes MellitusStanniocalcin 1Subcellular ProcessT2 DMT2DT2DMTC21TestingThesaurismosisTimeTissuesTransmissionType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWeight GainWeight IncreaseWhite Blood CellsWhite Celladiposityadult onset diabetesadulthoodagesbead chipbeta cell developmentbiologicbiological signal transductionbody weight gainbody weight increasecardiovascular disordercohortcomplementationcorpulencedevelopmentaldiabetesdiabetes pathogenesisdiabetes riskdiabeticdifferentiation of pluripotent stem cellsdiscovery miningdisease onsetdisorder onsetendocrine pancreas developmentenhancer sequenceepigenetic memoryepigenetic regulationepigeneticallyepigenomeepigenome wide association analysisepigenome-wide association studiesepigenomicsethnic subgroupethnicity groupgenetic enhancer sequencegenome scalegenome wide analysisgenome wide studiesgenome-widegenome-wide analysisgenome-wide identificationgenomewideglucose tolerancehazardhigh riskiPSiPSCiPSC technologyiPSCsimprintin uteroinduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cell technologyinducible pluripotent cellinducible pluripotent stem cellinorganic phosphateinsulin secretionisletislet developmentketosis resistant diabeteskidslater in lifelater lifeliterature miningliterature searchinglogarithmlogarithmiclong-term studylongitudinal outcome studiesmaternal diabetesmaturity onset diabetesmetabolism disordernon-diabeticnondiabeticnoveloffspringpathwayperipheral bloodpluripotent stem cell differentiationpostnatalprenatalprogenitor cell modelprogenitor modelsocial rolestanniocalcinstem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modeltext miningtext searchingtranscriptome sequencingtranscriptomic sequencingtranscriptomicstransmission processtype 2 DMtype II DMtype two diabetesunbornwhite blood cellwhite blood corpusclewt gainyoungsterβ-cellβ-cellsβCell
Description preview
Individuals exposed to maternal diabetes in utero are more likely to develop metabolic and cardiovascular diseases later in life. This may be partially attributable to epigenetic regulation of gene expression. To examine whether differential DNA methylation, a major source of epigenetic regulation, can be observed in offspring of mothers with type…
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