grant
Epigenetic modification of HIV-1 Cap
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 14 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20255' Capped RNA5' mRNA Cap StructureAIDS VirusAchievementAchievement AttainmentAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAnti-Retroviral AgentsAnti-viral TherapyBasic ResearchBasic ScienceBindingBlood PlasmaCell BodyCellsCellular StressCellular Stress ResponseChronicClampingsClinicalClosure by clampCommunicationComplexCoupledCryo-electron MicroscopyCryoelectron MicroscopyDataDetectionDevelopmentDocumentationDrug resistanceDrugsElectron CryomicroscopyEnvironmentEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumEvolutionFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2FoundationsFutureGene ExpressionGenerationsGoalsGuanosineHIVHIV Viral Protein RHIV vpr Gene ProductHIV-1HIV-1 vpr Gene ProductsHIV-IHIV1HomodimerizationHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1HypermethylationImmuneImmune Cell ActivationImmune signalingImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsInnate Immune ResponseIntervening SequencesIntronsKnowledgeLAV-HTLV-IIILicensingLinkLong-term infectionLymphadenopathy-Associated VirusMechanistic Target of RapamycinMediatingMedicationMessenger RNAMethylationModelingModificationMolecularMolecular ImmunologyMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMolecular ProbesMolecular VirologyMyeloid CellsNIAIDNational Institute of Allergy and Infectious DiseaseNon-Polyadenylated RNANuclearOutcomePathway interactionsPatientsPharmaceutical PreparationsPlasmaPlasma SerumPost-Transcriptional ControlPost-Transcriptional RNA ModificationPost-Transcriptional RNA ProcessingPost-Transcriptional RegulationPrecipitationPredispositionProcessProductionPropertyProteinsPublic HealthPublishingR Gene ProductsRAFT1RHA enzymeRNARNA CapsRNA Gene ProductsRNA helicase ARegulationReportingResearchReticuloendothelial System, Serum, PlasmaRibonucleic AcidRibonucleoproteinsRoleScientistShapesStructureSusceptibilityT-CellsT-LymphocyteTherapeuticTranscriptTranslationsValidationViralViral BurdenViral Gene ProductsViral Gene ProteinsViral GenesViral LoadViral Load resultViral ProteinsViral Regulatory ProteinsVirionVirus ParticleVirus ReplicationVirus-HIVWorkYinanti-retroviralarmbalancebalance functionbiological adaptation to stresscell stresschronic infectioncryo-EMcryoEMcryogenic electron microscopydevelopmentaldrug resistantdrug/agentdruggable targetepigeneticallyexhaustexhaustionexperienceexperimentexperimental researchexperimental studyexperimentsfundamental researchimmune activationinnovateinnovationinnovativeinsightmRNAmTORmammalian target of rapamycinmethyl groupmolecular modelingnovelpathogenic viruspathwaypersistent infectionpost-transcriptional gene regulationprecipitationspreventpreventingrap Gene Productsreaction; crisisrecruitresistance to Drugresistant to Drugrev-Responsive Elementssensorsmall moleculesocial rolestress responsestress; reactionstructural biologythymus derived lymphocytetooltranslationtranslational studyvalidationsviral RNAviral infectious disease treatmentviral multiplicationviral pathogenviral replicationvirologyvirus RNAvirus host interactionvirus multiplicationvirus pathogenvirus proteinvpr Gene Productsvpr Protein
Description preview
Project summary
Basic research opens the door to better understand, treat, and ultimately prevent existing and
emerging public health threats. NIAID has prioritized fundamental research into underpinnings of
the HIV-associated chronic immune activation despite the control of viral load by daily
antiretroviral medication. Recent findings of the…
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