grant
Epigenetic engrams in planarians
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AmputationAnimalsAntsBehaviorBehavioralBehavioral ParadigmBiogenesisBiologic ModelsBiological ModelsBrainBrain Nervous SystemChemicalsCloningComplexCoupledDataDecapitationEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFlatwormsFosteringFunctional RNAGeneticGenomicsGerm LinesHeadHereditaryHumanIndividualInheritedKnowledgeMammalian CellMediatingMemoryModel SystemModelingModern ManModernizationMolecularMolecular GeneticsMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsMovementNatural regenerationNatureNervous SystemNeurologic Body SystemNeurologic Organ SystemNeurosciencesNon-Polyadenylated RNANoncoding RNANontranslated RNAOrigin of LifePathway interactionsPlanariansPlatyhelminthesPlatyhelminthsPunishmentRNARNA Gene ProductsRegenerationRenaissanceReportingRewardsRibonucleic AcidStimulusSynapsesSynapticTrainingTransmissionUntranslated RNAbody movementchemical associationepigeneticallyexperienceforgettinggenomic toolsinsightmemory encodingmemory recallmemory retentionmodel organismmolecular modelingneuralneural circuitneural circuitryneurocircuitrynoncodingpathwayregeneratesynapsesynaptic circuitsynaptic circuitrytooltransgenerational epigenetic inheritancetransgenerational inheritancetransmission process
Description preview
ABSTRACT
Although selective synaptic remodeling within neural circuits is widely accepted as the molecular substrate for
storage of memories in the brain—the so called “engram”—evidence exists in different model organisms that
memories and behaviors can be encoded, and possibly transmitted, by RNA, suggesting that acquired neural
states can…
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