grant
Epigenetic Biomarkers in Glioblastoma
Organization GEORGETOWN UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 16 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAntigensBiological MarkersBlood SerumBrain NeoplasiaBrain NeoplasmsBrain TumorsCAR T cell therapyCAR T cellsCAR T therapyCAR modified T cellsCAR-TCAR-TsCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCancersCell BodyCell Surface AntigensCell SurvivalCell ViabilityCellsChildhood CancersClinical TrialsConsultationsCytometryDataDiseaseDisorderEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFutureGeneticGlial Cell TumorsGlial NeoplasmGlial TumorGlioblastomaGliomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematopoietic CancerHistopathologyImageImmune mediated therapyImmunoblottingImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImmunological Surface MarkersImmunologically Directed TherapyImmunotherapyIn VitroLinkMalignantMalignant - descriptorMalignant Childhood NeoplasmMalignant Childhood TumorMalignant Hematologic NeoplasmMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant childhood cancerMeasuresMessenger RNAMiceMice MammalsMolecularMurineMusNatureNecrosisNecroticNeuroglial NeoplasmNeuroglial TumorNewly DiagnosedNon-Polyadenylated RNAPDX modelPathway interactionsPatient derived xenograftPatientsPeripheralPolycombPrediction of Response to TherapyPrimary Brain NeoplasmsPrimary Brain TumorsPrognosisProliferatingProteinsRNARNA Gene ProductsRadiationRecurrenceRecurrentRecurrent NeoplasmRecurrent tumorRegulationResearchRibonucleic AcidRing FingerRing Finger DomainRing Finger MotifRing-Type Zinc Finger DomainSamplingSerumSolid NeoplasmSolid TumorSurface AntigensT cells for CARTemodalTemodarTestingTimeTumor AntigensTumor CellTumor-Associated AntigenUniversitiesWestern BlottingWestern Immunoblottingadulthoodbio-markersbiologic markerbiomarkercancer antigenscancer in a childcancer in childrencancer microenvironmentcell killingcell typechild with cancerchildhood malignancychimeric antigen T cell receptorchimeric antigen receptor (CAR) T cell therapychimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cell therapychimeric antigen receptor T cellschimeric antigen receptor T therapychimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellsclustered regularly interspaced short palindromic repeats screencohortcombatconsultationdifferential expressiondifferentially expresseddisialogangliosidesepigenetic biomarkerepigenetic markerepigeneticallyexosomegene networkglial-derived tumorglioblastoma multiformeimagingimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunotherapy clinical trialsin vivoinnovateinnovationinnovativeknock-downknockdownmRNAmalignancymethazolastonemonosialogangliosidesneoplasm recurrenceneoplasm/cancerneoplastic cellneuroglia neoplasmneuroglia tumornew drug treatmentsnew drugsnew markernew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel biomarkernovel drug treatmentsnovel drugsnovel markernovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwaypatient derived xenograft modelpatient stratificationpediatric cancerpediatric malignancypotential biological markerpotential biomarkerpredict responsivenesspredict therapeutic responsepredict therapy responsepredicting responseprotein blottingresponseresponse biomarkerresponse markerssialogangliosidesspongioblastoma multiformestandard of carestratified patienttemozolomidetherapy predictiontranscriptional differencestreatment predictiontreatment response predictiontumortumor growthtumor microenvironmenttumor-specific antigentumors in the brain
Description preview
PROJECT SUMMARY
Glioblastoma (GBM) is the most common malignant primary brain tumor in adults. Despite progress in
understanding the genetic and epigenetic underpinnings, GBM remains an incurable disease with a median
overall survival of approximately 15 months. Therefore, novel therapies are required to combat this disease.
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