grant
Epigenetic basis and therapeutic targeting of the unique lymphoma immunological niche
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 12 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AddressAgeAgingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBasic ResearchBasic ScienceBiologic ModelsBiological ModelsBiologyBiometricsBiometryBiostatisticsCancersCausalityCell BodyCell Communication and SignalingCell Fate ControlCell Fate RegulationCell SignalingCellsChromatinChromatin Remodeling ComplexChromatin Remodeling FactorClassificationClinicalClinical SciencesCommunitiesComplexDLBCLDNA mutationDataData AnalysesData AnalysisData BasesData SetDatabasesDevelopmentDiffuse Large B-Cell LymphomaDiseaseDisorderEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtiologyGEM modelGEMM modelGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetically Engineered MouseGenomicsGerminal CenterGerminoblastic SarcomaGerminoblastomaGoalsGraphical interfaceHost FactorHost Factor ProteinImageImmuneImmune mediated therapyImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologically Directed TherapyImmunologicsImmunotherapyInformaticsIntegration Host FactorsIntracellular Communication and SignalingKinasesLesionLife ExpectancyLinkLymphomaLymphoma cellLymphomagenesisMalignantMalignant - descriptorMalignant LymphomaMalignant NeoplasmsMalignant TumorMediatingMediatorMethodsModel SystemModelingMutationNatureP01 MechanismP01 ProgramPathogenesisPathologyPathway interactionsPhenotypePhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPopulationPrecision therapeuticsProcessProgram Project GrantProgram Research Project GrantsRNA ExpressionReactionResearch Program ProjectsResearch ResourcesResourcesReticulolymphosarcomaShapesSignal InductionSignal TransductionSignal Transduction SystemsSignalingSomatic MutationStructure of germinal center of lymph nodeSystematicsSystems BiologyTechnologyTherapeuticTherapeutic InterventionThinkingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranslatingTranslational ResearchTranslational ScienceTransphosphorylasesWorkage associated effectsage effectage related effectsagesaging effectaging processbiological heterogeneitybiological signal transductioncausationchromatin modifiercomputational pipelinesdata basedata interpretationdepositorydevelopmentaldisease causationdisease phenotypeepigeneticallyepigenomeexpression subtypesgenetically engineered mouse modelgenetically engineered murine modelgenome mutationgraphic user interfacegraphical user interfaceimagingimmune microenvironmentimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunological synapseimmunosuppressive microenvironmentimmunosuppressive tumor microenvironmentimpact of ageinfluence of ageinnovateinnovationinnovativeinsightintervention therapylarge cell Diffuse non-Hodgkin's lymphomamalignancymalignant statemolecular sub-typesmolecular subsetsmolecular subtypesneoplasm/cancerpathwayprecision therapiesprecision treatmentprogramsrepositorysoftware user interfacesomatic varianttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targetthoughtstranscription factortranslation researchtranslational investigationtumortumor eradicationtumor immune microenvironmenttumor-immune system interactions
Description preview
OVERALL: ABSTRACT
Diffuse large B-cell lymphoma (DLBCL) is an aggressiveand clinically heterogeneous malignancy derived from
B-cells transiting the germinal center (GC) reaction. Indeed, the biological heterogeneity of DLBCL aligns with a
continuum of developmental states within and subsequent to the GC reaction. The genetic hallmarks of DLBCL
are…
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