grant
Epigenetic and transcriptional mechanisms driving human pigmentation diversity
Organization UNIVERSITY OF OKLAHOMALocation NORMAN, UNITED STATESPosted 1 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AffectAnatomic SitesAnatomic structuresAnatomyAssayAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas9 screenCandidate Disease GeneCandidate GeneCell BodyCellsChromosome MappingCodeCoding SystemColorControl LocusCutaneous DisorderDNADarknessDeoxyribonucleic AcidDermatosesDiathesisDiseaseDisease susceptibilityDisorderEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionGWA studyGWASGene Copy NumberGene DosageGene ExpressionGene LocalizationGene MappingGene Mapping GeneticsGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ScreeningGenetic TranscriptionGenetic studyGenomeGenome engineeringGenotypeGoalsHair ColorHealthHumanHuman DevelopmentIn VitroInstructionKnowledgeLightLinkage MappingLocationMapsMeasurementMelaninsMelanogenesisMethodsMiceMice MammalsModelingModern ManMolecularMurineMusNatural SelectionsNormal RangeNormal ValuesPhenotypePhotoradiationPigmentationPigmentation physiologic functionPigmentsPlayPostdocPostdoctoral FellowProductionRNA ExpressionReporterResearch AssociateRoleSkin DiseasesSkin Diseases and ManifestationsSkin PigmentationTotal Human and Non-Human Gene MappingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenic MiceValidationVariantVariationWorkclustered regularly interspaced short palindromic repeats screencutaneous diseasedermal diseasedermal disorderdifferential expressiondifferentially expresseddifferentiation of pluripotent stem cellsdrivingepigeneticallyepigenome profilingepigenomic profilingexperimentexperimental researchexperimental studyexperimentsgenetic mappinggenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studyhuman population studyinsightliability to diseasemelanocytemouse modelmurine modelnovelpigmentpigmentationspluripotent stem cell differentiationpost-docpost-doctoralpost-doctoral traineeprogramsresearch associatesskin colorskin disordersocial roletraittranscription factortranscriptional differencesvalidationswhole genome association analysiswhole genome association study
Description preview
Melanin is the key determinant of human pigmentation that has evolved under natural selection and has led to
diversification of human skin color. Importantly, the number of melanin-producing-melanocytes and their
anatomical location do not vary among humans, only varying melanogenesis determines the human
pigmentation diversity. Our long-term goal…
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