grant
Epigenetic and Transcriptional Functions of Nuclear Receptors and Chromatin Remodeling Proteins in Stem and Cancer Cells
Organization NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025(TNF)-α20S Catalytic Proteasome20S Core Proteasome20S Proteasome20S Proteosome26 S proteasome complex26S ATP-Dependent Protease26S ATP-Dependent Proteasome26S Proteasome Complex26S Proteosome26S protease26S proteasomeAP-1AP-1 Enhancer-Binding ProteinAP1AP1 proteinAPF-1ATP-Dependent Proteolysis Factor 1AblationActivator Protein-1AffectAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAgeAmericanArchitectureAttentionAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBiologyCachectinCell BodyCell Communication and SignalingCell SignalingCell-Extracellular MatrixCellsChromatinChromatin Remodeling ComplexChromatin Remodeling FactorCollagen GeneCommunicationComplexCritical PathsCritical PathwaysCuesDNADNA-Dependent RNA Polymerase IIDataDeoxyribonucleic AcidDepositDepositionDermalDevelopmentDiseaseDisorderECMES cellEcological impactEnergy ExpenditureEnergy MetabolismEngineering / ArchitectureEnhancer-Binding Protein AP1EnhancersEnvironmentEnvironmental ImpactEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEukaryotic CellEuropeanExhibitsExtracellular MatrixFibroblastsGene Action RegulationGene Down-RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenomeGlucocorticoid ReceptorGoalsHMG-20HealthHeterochromatinHeterogeneityHigh Mobility Protein 20Histone AcetylationHistone H1Histone H1(s)HistonesHomeostasisHumanImmune responseInduced pluripotencyInduced pluripotent stateIntracellular Communication and SignalingLigandsLinker DNAMacropainMacrophage-Derived TNFMacroxyproteinaseMaintenanceMalignant CellMating Type Switching/Sucrose Nonfermenting ProteinMediatingMetabolic Protein DegradationMissionModern ManModificationMolecularMolecular InteractionMonocyte-Derived TNFMulticatalytic ProteinaseNIEHSNational Institute of Environmental Health SciencesNon-Polyadenylated RNANormal CellNuclear ReceptorsNucleic AcidsNucleosomal LinkerNucleosomesPatient Self-ReportPatternPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPlayPluripotent Stem CellsPolycombPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessProgenitor CellsProsomeProteasomeProteasome Endopeptidase ComplexProtein ModificationProtein TurnoverProteinsProteosomeRNARNA ExpressionRNA Gene ProductsRNA Polymerase BRNA Polymerase IIReceptor ProteinRegulatory Protein DegradationReportingReproductionResearchRibonucleic AcidRoleSWI/SNF ComplexSWI/SNF Family ComplexSamplingSelf-ReportSignal TransductionSignal Transduction SystemsSignalingSiteStem cell pluripotencyStrategic PlanningStructureSystemTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTrainingTranscriptTranscriptionTranscription Factor AP-1Transcription Factor Proto-OncogeneTranscription InitiationTranscription Initiation SiteTranscription RepressionTranscription Start SiteTranscription factor genesTumor Necrosis FactorTumor Necrosis Factor-alphaUbiquitinVariantVariationWorkagesbiological researchbiological signal transductioncancer cellcardiac functionchromatin modifierchromatin remodelingdevelopmentalembryo derived stem cellembryonal stem cellsembryonic progenitorembryonic stem cellenvironmental health disparityepigeneticallyfunction of the heartgene repressiongenetic informationglobal healthhESCheart functionhistone modificationhost responsehuman ES cellhuman ESChuman derived pluripotent stem cellhuman embryonic stem cellhuman pluripotent stem celliPSiPS biologyiPSCiPSC biologyiPSCsimmune system responseimmunoresponseimprovedinduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cell biologyinducible pluripotent cellinducible pluripotent stem cellmembermulticatalytic endopeptidase complexoutreachpermissivenesspluripotencypluripotent progenitorpluripotent stateposttranscriptionalpromoterpromotorprotein degradationreceptorresponsesocial rolestem cell of embryonic originstem cellstranscription factortranscriptomicstriptolide
Description preview
The elegant organization of nucleic acids, predominantly DNA, into chromatin serves essential structural and regulatory roles in eukaryotic cells. This beautiful architecture allows for an expansion of the underlying genetic information by overlaying a spectrum of epigenetic controls. The interplay between genome accessibility, chromatin…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click