grant
Epigenetic and metabolic mechanisms of environmentally-induced transgenerational germline dysfunction
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Jun 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20260-11 years oldAbsolute ethanolAcetate ThiokinaseAcetate-CoA LigaseAcetatesAcetothiokinaseAcetyl Activating EnzymeAcetyl CoAAcetyl CoA SynthetaseAcetyl Coenzyme AAcetyl Coenzyme A SynthetaseAcetylationAddressAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsApoptosisApoptosis PathwayAutomobile DrivingBindingBiologic ModelsBiological ModelsBody TissuesBrainBrain Nervous SystemC elegansC. elegansC.elegansCUT&RUNCaenorhabditis elegansChildChild YouthChildren (0-21)ChromatinChromosomal SynapsisChromosome PairingCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCommon Rat StrainsComplexCytologyDNA RecombinationDataDefectDiseaseDisorderDrosophilaDrosophila genusDysfunctionETOHEcological impactEmbryoEmbryonicEncephalonEnvironmentEnvironmental ExposureEnvironmental ImpactEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtOH drinkingEtOH useEthanolEthanol MetabolismEthyl AlcoholEventExposure toFetal Alcohol ExposureFetal Alcohol SyndromeFetal ETOH ExposureFetal Ethanol ExposureFoundationsFunctional disorderFuture GenerationsGametesGenerationsGeneticGenetic RecombinationGenomeGerm CellsGerm LinesGerm-Line CellsGestationGoalsGrain AlcoholHeritabilityHistone AcetylationHistonesHumanIn Utero Alcohol ExposureIn Utero ETOH ExposureIn Utero Ethanol ExposureIncidenceKnowledgeLinkMammaliaMammalsMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatorMeiosisMemoryMetabolicMetabolic PathwayMethylcarbinolMiceMice MammalsModel SystemModelingModern ManModificationMolecularMolecular InteractionMorphologyMurineMusNematodaNematodesNeurologicNeurologicalNuclearOrganismOutcomePathway interactionsPhysiologicPhysiologicalPhysiopathologyPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPregnancyPrenatal Alcohol ExposurePrenatal ETOH ExposurePrenatal Ethanol ExposureProgrammed Cell DeathProtein ModificationRatRats MammalsRattusRecombinationRegulationReportingReproductionReproductive CellsReproductive FactorsReproductive HistoryReproductive History EpidemiologyReproductive IssuesResearchRodent ModelS-acetate Coenzyme ASeminalSex CellSymptomsSynapsisTestingTissuesTransmissionWestern EuropeWomanWorkalcohol effectalcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol metabolismalcohol product usealcohol responsealcohol testingalcohol usealcohol-exposed pregnancyalcoholic beverage consumptionalcoholic drink intakealcoholic embryopathybehavioral impairmentdesigndesigningdrivingembryofetal alcohol syndromeembryopathia alcoholicaepigeneticallyepigenomeepigenomicsethanol consumptionethanol drinkingethanol effectethanol exposedethanol exposureethanol ingestionethanol intakeethanol product useethanol responseethanol testingethanol useexposed in uteroexposed to alcoholexposed to alcohol prenatallyexposed to ethanolexposure to alcoholexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesexposure to ethanolfetalfetal exposurefruit flygestation ETOH exposuregestation alcohol exposuregestation ethanol exposuregestational ethanol exposurehistone modificationhomologous recombinationimpaired behaviorin utero exposureinitial cellintra-uterine environmental exposureintrauterine environmental exposurekidsliving systemmeioticmodel organismneurobehavioralpathophysiologypathwaypharmacologicpreferencepregnancy ETOH exposurepregnancy alcohol exposurepregnancy ethanol exposureprenatal exposureprenatally alcohol exposedprenatally exposedprenatally exposed to alcoholprogramsreproductivereproductive functionreproductive outcomeresponse to alcoholresponse to ethanolroundwormsexual cellstemtooltransgenerational epigenetic inheritancetransgenerational inheritancetransmission processyoungster
Description preview
PROJECT SUMMARY
The overarching goal of the research presented in this application is to dissect the genetic, epigenetic, and
metabolic programs that encode and transmit a memory of environmental exposure for several generations. In
that context, we aim to understand how environmental influences alter the reproductive program of organisms
in a…
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