grant
Environmental adaptation by Vibrio cholerae
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 3 Aug 2018Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AI-2 autoinducerAcute DiarrheaAddressAdherenceAffectCell BodyCell Communication and SignalingCell DensityCell SignalingCell divisionCellsCholeraConsumptionCuesDehydrationDevelopmentDiarrheaDiseaseDisorderDown-RegulationDrug EffluxEcologic SystemsEcological SystemsEcosystemEpidemicFe elementFeedbackFoodGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneralized GrowthGenesGenetic TranscriptionGram-Negative BacteriaGrowthHumanImpairmentIn VitroInfectionIngestionIntermediary MetabolismIntestinalIntestinesIntracellular Communication and SignalingIronLife CycleLife Cycle StagesLinkMediatingMetabolic ProcessesMetabolismMicrobial BiofilmsModelingModern ManN-octanoyl-L-homoserine lactonePaperPathogenesisPathogenicity FactorsPeriplasmic SpacePersonsPhenotypeProcessProductionProteinsRNA ExpressionRegulonRepressionResearchResistanceResistance to infectionSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSmall IntestinesSystemTestingTissue GrowthToxinTranscriptionTransmissionUpregulationV choleraeV. choleraeVAI-2Vibrio choleraeVibrio commaVirulenceVirulence FactorsWater contaminationaquatic organismautoinducer 2bile saltsbiofilmbiological signal transductionbody water dehydrationbowelcombatcontaminated waterdevelopmentaldiarrheal diseasediarrheal illnessenvironmental adaptationhuman diseasehuman pathogenin vivo Modelinfection resistanceingestlife coursemutantnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathogenpathogenicity geneperiplasmpurgepurgespurgingquorum sensingresistantresponsesensorsmall boweltransmission processvirulence genevirulent gene
Description preview
PROJECT SUMMARY/ABSTRACT
Cholera is an acute diarrheal disease that affects 3-5 million people each year. Cholera is an is
caused by the Gram negative bacterium Vibrio cholerae and is frequently associated with epidemic
disease. V. cholerae is a native to aquatic ecosystems and a facultative human pathogen that infects
people through the…
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