grant
Envelope biogenesis in Escherichia coli and Pseudomonas aeruginosa
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Jan 2010Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025Acyl Carrier ProteinAddressAnti-Bacterial AgentsAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsArchitectureAreaBackBacteriaBacterial O AntigenBindingBiochemicalBiogenesisBiologic ModelsBiologicalBiological ModelsCapsulesCell BodyCell Membrane PermeabilityCell WallCell divisionCell surfaceCellsCellular ExpansionCellular GrowthCellular biologyColiform BacilliComplexCytolysisDevelopmentDorsumDrug resistanceDrugsE coliE. coliEducational process of instructingEngineering / ArchitectureEnsureEnteric BacteriaEnterobacteriaEnterobacteriaceaeEnzyme GeneEnzymesEquilibriumEscherichia coliEsteroproteasesFeedbackFortificationFundingGeneralized GrowthGeneticGlycansGlycolipidsGoalsGram-Negative BacteriaGrowthHealthHumanHydrophobicityImpairmentIn VitroIndividualInfectionLateralLeannessLearningLinkLipidsLipopolysaccharidesLysisMediatingMedicationMembraneMicrobiologyMiscellaneous AntibioticModel SystemModern ManMolecularMolecular InteractionMureinNatureO AntigensO-Specific PolysaccharidesOrganismOrigin of LifeOsmosisP aeruginosaP. aeruginosaPathway interactionsPenicillinsPeptidasesPeptide HydrolasesPeptidoglycanPharmaceutical PreparationsPhosphatesPhosphatidesPhospholipidsPolymerasePolymersPolysaccharidesProcessProductionProtease GeneProteasesProtein CleavageProteinasesProteinsProteobacteriaProteolysisProteolytic EnzymesPseudomonas aeruginosaPseudomonas pyocyaneaPurple BacteriaRegulatory PathwayResearch ProposalsResistance to antibioticsResistant to antibioticsRoleSourceStructureSurfaceSystemTeachingThinnessTimeTissue GrowthWorkanti-bacterialantibiotic drug resistanceantibiotic resistantbalancebalance functionbiologiccapsulecell biologycell envelopecell growthcombatdevelopmentaldrug resistantdrug/agentexperimentexperimental researchexperimental studyexperimentsfrontierinorganic phosphateinsightliving systemmembrane biogenesismembrane permeabilitymembrane structuremonomernew antibiotic classnew antibiotic typenovelnovel antibiotic classontogenypathogenpathwaypolymerpolymericpreventpreventingprogramsresistance to Drugresistant to Drugsocial rolesugar
Description preview
SUMMARY
A major goal of bacterial cell biology is to understand the mechanisms underlying the assembly and growth of
the cell envelope. In addition to addressing a fundamental biological question, studies in this area have significant
consequences for human health because the envelope serves as both a major target for antibiotics and, in the
case…
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