grant
Enterovirus interference with rotavirus vaccine replication and immunity
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 12 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025(TNF)-α0-11 years old21+ years oldAdultAdult HumanCachectinCell Communication and SignalingCell SignalingCessation of lifeChildChild YouthChildhoodChildren (0-21)ClinicalClinical TrialsCountryCoxsackie VirusesCoxsackievirusDataDeathDevelopmentDiarrheaEconomic IncomeEconomical IncomeEnteralEntericEnterovirusEnterovirus InfectionsEnvironmentEpithelial CellsEpitheliumEvidence based interventionFamily PicornaviridaeGhanaGoalsGold CoastGut EpitheliumHospital AdmissionHospitalizationHost FactorHost Factor ProteinHumanIFNImmuneImmune responseImmunesImmunityImmunomodulationIncomeInfantInfectionInnate Immune ResponseIntegration Host FactorsInterferonsIntestinalIntestinesIntracellular Communication and SignalingInvestigatorsKO miceKnock-out MiceKnockout MiceLMICLifeMacrophage-Derived TNFMediatingMiceMice MammalsModelingModern ManMolecularMonocyte-Derived TNFMorbidityMorbidity - disease rateMurineMusNorthern RhodesiaNull MouseOralOral Polio VaccineOral Poliovirus VaccineOrganoidsOutcomePathway interactionsPerformancePicornaviridaePicornavirusesRNA VirusesResearch PersonnelResearchersRiskRoleRotavirusRotavirus InfectionsRotavirus VaccinesRotavirus diseaseSabin VaccineSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSystemTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTestingTimeTransgenic OrganismsTumor Necrosis FactorTumor Necrosis Factor-alphaVaccinationVaccinesVariantVariationViralViral InterferenceWorkZambiaadaptive immune responseadaptive immunityadulthoodbiological signal transductionbowelclinical efficacyco-infectioncohortcoinfectioncompare effectivenesscytokinedevelopmentalfecal samplegastrointestinal epitheliumhost responseimmune modulationimmune regulationimmune response to vaccinationimmune response to vaccinesimmune system responseimmunogenicityimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimprovedin vivoincomesinnate immune pathwaysinsightinterfering viruskidsknockout genelow and middle-income countriesmortalitymouse modelmurine modeloral vaccinepathwaypediatricpreventpreventingseroconversionsocial rolestool samplestool specimentransgenicvaccination studyvaccination trialvaccine associated immune responsevaccine effectivenessvaccine efficacyvaccine immune responsevaccine immunogenicityvaccine induced immune responsevaccine responsevaccine responsivenessvaccine studyvaccine trialvaccine-induced responsevaccinologyviral microbiomeviromevirus virus interactionyoungster
Description preview
PROJECT SUMMARY/ABSTRACT
Rotavirus (RV) is the leading cause of diarrhea-associated morbidity and mortality in children younger
than five worldwide. While RV vaccines have substantially decreased RV deaths, children in low- and middle-
income countries remain at risk of life-threatening RV disease because of significantly lower vaccine…
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