grant
Enrichment for Tumor-derived Cell-free EBV DNA: Towards a Diagnostic Assay for Endemic Burkitt Lymphoma
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY20250-11 years oldAbdomenAbdominal MassAccuracy of DiagnosisAffectAfricaAfricanAfrican Burkitt's lymphomaAfrican LymphomaAgeAssayBioassayBiological AssayBiopsyBloodBlood PlasmaBlood Reticuloendothelial SystemBody FluidsBuffersBulky DiseaseBurkitt HerpesvirusBurkitt Lymphoma VirusCNS DiseasesCNS disorderCancersCell BodyCell CoatCellsCentral Nervous System DiseasesCentral Nervous System DisordersCentrifugationCentrifugation FractionationCharacteristicsChildChild YouthChildhood CancersChildren (0-21)ClinicalCold ChainsCollectionCommunitiesCountryCystCytolysisDNADNA MethylationDeoxyribonucleic AcidDetectionDevelopmentDiagnosisDiagnosticDiagnostic SpecificityDiseaseDisease ProgressionDisorderEB virusEBVEBV associated tumorEBV induced tumorEBV latencyEBV malignanciesEBV related tumorEBV(+) malignancyEBV-Related MalignancyEBV-associated cancersEBV-associated malignancyEBV-positive cancerEBV-positive malignancyEBV-positive malignant tumorEBV-related cancerEDTAEarly DiagnosisEconomic IncomeEconomical IncomeEdathamilEdetic AcidEndemic Burkitt's LymphomaEnlarged SpleenEnrollmentEpidemic ParotitisEpithelial CellsEpitheliumEpstein Barr VirusEpstein Barr Virus MalignancyEpstein Barr Virus associated cancersEpstein Barr Virus associated tumorEpstein Barr Virus positive cancerEpstein-Barr Virus associated malignancyEpstein-Barr Virus latencyEpstein-Barr Virus-Related MalignancyEpstein-Barr Virus-Related Malignant NeoplasmEthylenediaminetetraacetic AcidEthylenedinitrilotetraacetic AcidExclusionExtravasationFutureGlycocalyxHHV-4HHV4HistologicHistologicallyHistopathologyHourHuman Herpesvirus 4IncomeIndividualInfectious Mononucleosis VirusInferiorInvestigationJawLeakageLymphatic cellLymphocyteLymphocyticLysisMalariaMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant childhood cancerMeasurementMeasuresMethodsMethylationMonitorMumpsNon-MalignantOutcomePBMCPaludismParasitic infectionPatientsPerformancePeripheral Blood Mononuclear CellPlasmaPlasma SerumPlasmodium InfectionsPreparationProceduresProcessRecoveryResearch SpecimenReticuloendothelial System, Serum, PlasmaSalivaScienceScreening for cancerSensitivity and SpecificitySpecificitySpecimenSpecimen HandlingSpecimen ProcessingSpillageSplenomegalySterilitySwellingSymptomsTechniquesTemperatureTestingTimeTooth AbscessTranslatingTransportationTransudateTreatment FailureTubeTumor Lysis SyndromeTumor TissueTumor-DerivedUgandaVirionVirusVirus ParticleWhole Bloodagesanti-microbialantimicrobialcancer in a childcancer in childrencell free DNAcell free circulating DNAchemotherapychild with cancerchildhood malignancydental abscessdevelopmentaldiagnostic abilitydiagnostic accuracydiagnostic assaydiagnostic biomarkerdiagnostic capabilitydiagnostic markerdiagnostic powerdiagnostic utilitydiagnostic valueearly biomarkersearly cancer detectionearly detectionearly detection biomarkersearly detection markersenrollepidemic parotiditisexperienceimprovedincomesinfected with parasitesinnovateinnovationinnovativekidslymph cellmalignancyneoplasm/cancernonmalignantoral cavity epitheliumoral epitheliaoral epitheliumparasite infectionpediatric cancerpediatric malignancypreparationssaliva assaysaliva based assaysaliva based testsaliva testsalivary assaysalivary testscreening cancer patientsseropositivesexsteriletherapy failuretumortumor DNAtumor cell DNAtumor-specific DNAviral DNAvirus DNAyoungster
Description preview
PROJECT SUMMARY
Endemic Burkitt lymphoma (eBL) outcomes in children with advanced stage disease are markedly inferior to
those in children with early-stage disease. eBL is one of the most rapidly growing tumors. As a result, diagnostic
delays of days-to-weeks contribute to late presentations, and directly affect stage and curability of disease.…
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