grant
Enhancing Sleep Spindle Activity through Thalamic TI-TES: Neuromodulatory Foundations for Targeting Thalamocortical Dysfunction in Schizophrenia
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AddressAdvanced DevelopmentAffectAlgorithmsAnteriorAntipsychotic AgentsAntipsychotic DrugsAntipsychoticsAreaBilateralBiological MarkersBrainBrain Nervous SystemBrain regionCephalicChronicClinicalClinical TrialsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCouplingCranialCross-Over DesignsCrossover DesignDataDeep Brain StimulationDetectionDiseaseDisorderDisturbance in cognitionDrugsDysfunctionE-stimEEGEffectivenessElectric StimulationElectroencephalogramElectroencephalographyEncephalonFoundationsFrequenciesFunctional disorderFutureGenerationsGoalsHumanImpaired cognitionImpairmentIndividualInterventionLinkLiteratureLocationMajor TranquilizersMajor Tranquilizing AgentsMedicationMethodsModern ManNIMHNREMNappingNational Institute of Mental HealthNeurobiologyNeuroleptic AgentsNeuroleptic DrugsNeurolepticsOutcomeParietalParticipantPathway interactionsPatientsPharmaceutical PreparationsPhysiopathologyRandomizedResearchSchizophreniaSchizophrenic DisordersSeveritiesSleepSleep StagesSleep disturbancesStrategic PlanningStructureSymptomsTechniquesThalamic structureThalamusTherapeuticWorkaberrant sleepbio-markersbiologic markerbiomarkerclinical applicabilityclinical applicationcognitive dysfunctioncognitive lossdementia praecoxdensitydisrupted sleepdisturbed sleepdrug/agentelectric fieldelectrostimulationfeasibility trialfunctional outcomesimpaired sleepimprovedinnovateinnovationinnovativeinsightirregular sleepneuralneural controlneural regulationneurobiologicalneuromodulationneuromodulatoryneuropsychiatric diseaseneuropsychiatric disorderneuroregulationnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynon rapid eye movementnon-REMnon-invasive brain stimulationnon-rapid eye movementnonREMnonrapid eye movementnovelnovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwayrandomisationrandomizationrandomly assignedrestorationschizophrenia spectrumschizophrenia spectrum disorderschizophrenicsleep abnormalitiessleep disruptionsleep dysregulationsleep spindlesleep/wake disruptionsleep/wake disturbancethalamictherapeutic targettherapeutically effective
Description preview
PROJECT SUMMARY
Sleep spindle deficits are a promising biomarker and therapeutic target for schizophrenia spectrum disor-
der (SSD), as they reflect underlying dysfunction in thalamocortical circuits. However, current non-invasive
neuromodulation techniques lack the depth and precision to directly target deep brain structures like the thala-
mus,…
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