grant
Enhancing Editing Efficiency, Versatility and Guide Design of CHyMErA Screening Platform
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AbscissionAlgorithm DesignAlgorithmic DesignAlgorithmic EngineeringAssayAutomobile DrivingBase SequenceBioassayBiological AssayCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancer BiologyCas nuclease technologyCatalogsCell BodyCell Growth in NumberCell LineCell MultiplicationCell ProliferationCellLineCellsCellular ProliferationCharacteristicsClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoupledDNA DamageDNA InjuryDataData BasesDatabasesDeletion of DNA SequencesDependenceEffectivenessElementsEssential GenesExcisionExhibitsExonsExtirpationGene CombinationsGene Down-RegulationGene TargetingGene TranscriptionGenesGeneticGenetic ScreeningGenetic TranscriptionGenomicsGoalsGuide RNAHigh Throughput AssayHuman Cell LineHuman GenomeHybridsIndividualLibrariesLinkMalignant CellMammalian CellMapsNucleotide SequenceOutcomePathway interactionsPerformancePhenotypeRNA ExpressionRNA libraryRemovalSequence DeletionSiteStrains Cell LinesSurgical RemovalSystemTranscriptionTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscription RepressionTranscription RepressorTranscriptional Activator/CoactivatorTranscriptional RepressorValidationVariantVariationWorkadvanced systemalgorithm engineeringalgorithmic compositioncancer cellcatalogcombinatorialcultured cell linedata basedesigndesigningdrivingexperimentexperimental researchexperimental studyexperimentsfitnessflexibilityflexiblefunctional genomicsgRNAgene repressiongenetic repressorgenome editinggenomic deletiongenomic editinghigh throughput screeninghuman whole genomeimprovedinternet resourceknockout genemouse genomenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetnucleasenucleic acid sequenceon-line compendiumon-line resourceonline compendiumonline resourceparalogparalogous genepathwaypromoterpromotorrecruitresectionresponsescaffoldscaffoldingscreeningscreeningsuser-friendlyvalidationsweb resourceweb-based resource
Description preview
We have successfully developed a suite of cell lines expressing diverse Cas12a variants and conducted comprehensive functional screening using our Cas9-Cas12a CHyMErA platform, in conjunction with an optimized hgRNA library. These screens identified Cas12a variants exhibiting enhanced precision and editing efficiency compared to wild-type…
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