grant
Enhancing C. difficile vaccination in the context of TcdB-mediated immunosuppression.
Organization UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTRLocation OKLAHOMA CITY, UNITED STATESPosted 25 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AdoptedAmino Acid SequenceAnimalsAntibody ResponseAntigenic DeterminantsAntigensBinding DeterminantsC diffC difficileC. diffC. diff vaccineC. difficileC. difficile vaccineCell BodyCellsCessation of lifeClinical TrialsClostridioides difficileClostridioides difficile vaccineClostridium difficileClostridium difficile vaccineCombination VaccinesCombined VaccinesCricetinaeDataDeathDiseaseDisorderDrug Metabolic DetoxicationDrug Metabolic DetoxificationEffectivenessEnsureEpitopesEventFDA approvedFutilityGenerationsGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGlycansGoalsHamstersHamsters MammalsHu-mABsHumanImmuneImmune Cell ActivationImmune memoryImmune responseImmunesImmunologic MemoryImmunological MemoryImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInfectionInvestigationMediatingMemoryMetabolic Drug DetoxicationsMetabolism of Toxic AgentsMiceMice MammalsModelingModern ManMurineMusPathogenicity FactorsPhase 3 Clinical TrialsPhase III Clinical TrialsPolysaccharidesPrimary Protein StructureProductionProteinsPublishingRecombinant DNA TechnologyRelapseReportingRodentRodentiaRodents MammalsStructureTestingToxic effectToxicitiesToxinToxoidsVaccinatedVaccinationVaccinesVirulenceVirulence FactorsWorkanamnestic reactiondesigndesigningdetoxificationexperimentexperimental researchexperimental studyexperimentsgastrointestinalgenetically engineeredhost responsehumAbshuman mAbshuman monoclonal antibodieshuman monoclonalsimmune activationimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunogenimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responsein vivomemory recallmouse modelmurine modelmutantneutralizing antibodynew vaccinesnext generationnext generation vaccinesnovelnovel vaccinespathogenphase III protocolpreventpreventingprotein sequenceresponsesecondary immune responsevaccine candidatevaccine effectivenessvaccines against C . Difficilevaccines against Clostridioides difficile
Description preview
PROJECT SUMMARY (Project 1)
The most recent reports indicate Clostridioides difficile is the cause of over 400,000 cases of gastrointestinal
illness and nearly 30,000 deaths annually. The goals of this project are to develop an effective next generation
vaccine to prevent C. difficile disease and investigate the virulence-related activities of C.…
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