grant

Enhancing Alzheimer's-related research in rural South Africa with portable MRI

Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Feb 2025Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY202621+ years oldAD and related dementiaAD dementiaAD related dementiaADRDAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdultAdult HumanAffectAfricaAfricanAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAmentiaAmyloidAmyloid SubstanceAssayAtrophicAtrophyBioassayBiological AssayBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBrain Vascular DisordersBrain imagingCerebrovascular DiseaseCerebrovascular DisordersClinicalClinical DataCognitionCognitiveCollaborationsCommunicationCommunitiesCommunity HealthConsensusCoupledDataData CollectionDementiaDevelopmentDiagnosticDysfunctionEnsureEpidemiologyFunctional disorderFutureGeneral RadiologyGoalsHIVHealthHealth Care FacilityHealth FacilitiesHuman Immunodeficiency VirusesIncidenceIncidental FindingsInfrastructureInterviewIntracranial Vascular DiseasesIntracranial Vascular DisordersInvestigatorsLAV-HTLV-IIILMICLeadershipLongitudinal StudiesLongitudinal SurveysLumbar PunctureLymphadenopathy-Associated VirusMR ImagingMR TomographyMRIMRI ScansMRIsMT-bound tauMagnetic Resonance ImagingMagnetic Resonance Imaging ScanMeasurementMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMolecularNMR ImagingNMR TomographyNerve DegenerationNeurologic ExaminationNeuron DegenerationNeurosciencesNuclear Magnetic Resonance ImagingOutcomePETPET ScanPET imagingPETSCANPETTParticipantPathogenesisPhasePhysiopathologyPlasmaPlasma SerumPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrevalencePrimary Senile Degenerative DementiaProtocolProtocols documentationPublicationsRad.-PETRadiologyRadiology SpecialtyResearchResearch InfrastructureResearch PersonnelResearch ResourcesResearchersResourcesReticuloendothelial System, Serum, PlasmaRisk FactorsRuralScanningScientific PublicationScientistSouth AfricaSouth AfricanSpinal PunctureSurvey InstrumentSurveysSystemTechnologyTestingUniversitiesVirus-HIVWitWorkZeugmatographyadulthoodagedagesbio-markersbiologic markerbiomarkerbrain MR imagingbrain MRIbrain atrophybrain magnetic resonance imagingbrain vascular diseasebrain vascular dysfunctionbrain visualizationcare facilitiescerebral MR imagingcerebral MRIcerebral atrophycerebral magnetic resonance imagingcerebral vascular diseasecerebral vascular dysfunctioncerebrovascular dysfunctioncognitive assessmentcognitive testingcohortcommunity-based healthcomputerized data processingcortical atrophycostdata exchangedata processingdata transferdata transmissiondementia riskdevelopmentalepidemiologicepidemiologicalglobal healthimaging studyinformantintracranial vascular dysfunctionlong-term studylongitudinal outcome studieslongitudinal research studylow and middle-income countriesmicrotubule bound taumicrotubule-bound tauneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneuroimagingneurological degenerationneurological imagingneuronal degenerationpathophysiologypopulation basedportabilitypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprimary degenerative dementiaregional atrophyrisk factor for dementiarisk for dementiarural South Africarural arearural localityrural locationrural placerural regionrural settingsenile dementia of the Alzheimer typesocial determinantssocial factorssocial health determinantssociodeterminanttautau Proteinstau factortraining opportunityvascular componentvascular factorτ Proteins
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PROJECT SUMMARY
This project will incorporate portable, low-field brain magnetic resonance imaging (MRI) into a population-
representative study of Alzheimer’s disease (AD) and related dementias (ADRD) in rural South Africa,
transforming the ability to assess ADRD-related brain atrophy and cerebrovascular disease in low- and middle-
income country…

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Enhancing Alzheimer's-related research in rural South Africa with portable MRI — COLUMBIA UNIVERSITY HEALTH SCIENCES | U | Dev Procure