grant
ENHANCEMENT OF CD4CAR T-CELL PERSISTENCE IN VIVO
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 5 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdherenceAdoptive Cell TransfersAgonistAllogenicAntigensAntitumor ResponseApplications GrantsAssayAttentionBindingBioassayBiological AssayCAR T cell therapyCAR T cellsCAR T therapyCAR modified T cellsCAR-TCAR-TsCancersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChronicCollaborationsCommunicable DiseasesCommunicationCommunitiesDNA TherapyDataDimensionsDiseaseDisease ProgressionDisease remissionDisorderDrug KineticsEngineeringFosteringFutureGene Transfer ClinicalGenetic InterventionGoalsGrant ProposalsHIVHIV InfectionsHSC transplantationHTLV-III InfectionsHTLV-III-LAV InfectionsHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsIL-15IL15IL15 ProteinImmuneImmune mediated therapyImmune responseImmunesImmunologic SubtypingImmunologically Directed TherapyImmunophenotypingImmunotherapyIn VitroIndividualInfectionInfectious DiseasesInfectious DisorderInstitutionInterleukin-15Interleukin-15 PrecursorInterruptionIntracellular Communication and SignalingLAV-HTLV-IIILaboratoriesLearningLigandsLong-term infectionLymph Node Reticuloendothelial SystemLymph node properLymphadenopathy-Associated VirusLymphatic nodesLytotoxicityMGC9721Malignant NeoplasmsMalignant TumorMeasuresMembraneMentorsModelingMolecular InteractionNHP modelsOutcomePersonsPharmacokineticsPhysiciansPositionPositioning AttributePrincipal InvestigatorProliferatingPublic HealthPublicationsRemissionResearchSafetyScientific InquiryScientific PublicationScientistSeriesSignal TransductionSignal Transduction SystemsSignalingSubcellular ProcessT Cell SpecificityT cell receptor based immunotherapyT cell receptor cellular immunotherapyT cell receptor engineered therapyT cell receptor immunotherapyT cell responseT cells for CART-Cell ActivationT-Cell Immunologic SpecificityT-Cell ProliferationT-Cell Receptor TherapyT-Cell Receptor TreatmentT-Cell Receptor based TherapyT-Cell Receptor based TreatmentT-CellsT-LymphocyteTCR T cell immunotherapyTCR T cell therapyTCR TherapyTCR based T cell immunotherapyTCR based TherapyTCR based immune therapyTCR based immunotherapyTCR based treatmentTCR immunotherapyTechnical ExpertiseTestingToxic effectToxicitiesTrainingTranslatingTransmissionViralViral BurdenViral LoadViral Load resultViremiaVirionVirusVirus ParticleVirus ReplicationVirus-HIVWritingaccess to health careaccess to medicationsaccessibility of health careaccessibility to health careactivate T cellsadoptive cell therapyadoptive cellular therapyanti-tumor responseantiretroviral therapyantiretroviral treatmentbiological signal transductionblood stem cell transplantationcareercell killingchimeric antigen T cell receptorchimeric antigen receptorchimeric antigen receptor (CAR) T cell therapychimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cell therapychimeric antigen receptor T cellschimeric antigen receptor T therapychimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellschronic infectionconferenceconventioncytokinecytotoxicitydesigndesigningdetermine efficacyefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexhaustionexperiencefunctional improvementgene repair therapygene therapygene-based therapygenetic therapygenomic therapyhealth care accesshealth care availabilityhealth care service accesshealth care service availabilityhematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic progenitor cell transplantationhigh riskhost responseimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunoresponseimprove functionimproved functional outcomesin vivoinfectious disease treatmentinsightlymph glandlymph nodeslymphnodesmalignancymedication accessmembrane structureneoplasm/cancernext generationnon-human primatenonhuman primatenonhuman primate modelsnovelpersistent infectionpreventpreventingresponse to therapyresponse to treatmentsuccesssummitsymposiasymposiumtechnical skillstherapeutic responsetherapy responsethymus derived lymphocytetraffickingtransmission processtreatment responsetreatment responsivenesstreatment strategyviraemiaviral multiplicationviral reboundviral replicationviral sepsisvirus multiplicationvirus reboundvirusemia
Description preview
PROJECT SUMMARY/ABSTRACT
HIV is a chronic infection requiring long-term antiretroviral therapy (ART) to halt viral replication and
prevent disease progression. Despite highly effective ART, issues remain with medication access, adherence,
and tolerability. When ART is stopped, the virus rebounds from a reservoir of long-lived infected cells with…
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