Enhanced macromolecular structure modeling and validation methods for cryo-EM maps

Biomolecules, proteins and nucleic acids, carry out almost all tasks inside living cells. To understand how such molecules work and how to design new drugs that bind to them, their three-dimensional (3D) structures are crucial. Recently, cryogenic electron microscopy (cryo-EM) has allowed scientists to visualize these biomolecules as 3D volume…